Chemical Safety Data Sheet MSDS / SDS
Nimetazepam
Revision Date:2026-03-20Revision Number:1
Product identifier
- Product name: Nimetazepam
- CBnumber: CB6139366
- CAS: 2011-67-8
- EINECS Number: 217-931-5
- Synonyms: Hypnon
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.
Hazard statements
H225 Highly Flammable liquid and vapour
H370 Causes damage to organs
Substance
- Product name: Nimetazepam
- Synonyms: Hypnon
- CAS: 2011-67-8
- EC number: 217-931-5
- MF: C16H13N3O3
- MW: 295.29
Description of first aid measures
General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
After inhalation
Supply fresh air; consult doctor in case of complaints.
After skin contact
Generally the product does not irritate the skin.
After eye contact
Rinse opened eye for several minutes under running water.
After swallowing
Immediately call a doctor.
Information for doctor
Most important symptoms and effects, both acute and delayed
No further relevant information available.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.
Extinguishing media
Suitable extinguishing agents
Use fire fighting measures that suit the environment.
A solid water stream may be inefficient.
A solid water stream may be inefficient.
Special hazards arising from the substance or mixture
No further relevant information available.
Advice for firefighters
Protective equipment
No special measures required.
NFPA 704
0
3
0
| HEALTH | 0 | Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Not required.
Environmental precautions
Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up
Pick up mechanically.
Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
Protective Action Criteria for Chemicals
PAC-1
Substance is not listed.
PAC-2
Substance is not listed.
PAC-3
Substance is not listed.
Handling
Precautions for safe handling
No special precautions are necessary if used correctly.
Avoid breathing dust/fume/gas/mist/vapours/spray.
Avoid prolonged or repeated exposure.
Keep away from sources of ignition.
Take precautionary measures against static discharge.re.
Avoid breathing dust/fume/gas/mist/vapours/spray.
Avoid prolonged or repeated exposure.
Keep away from sources of ignition.
Take precautionary measures against static discharge.re.
Information about protection against explosions and fires
No special measures required.
Conditions for safe storage, including any incompatibilities
Storage
Store in accordance with information listed on the product insert.
Requirements to be met by storerooms and receptacles
No special requirements.
Information about storage in one common storage facility
Not required.
Further information about storage conditions
None.
Specific end use(s)
No further relevant information available.
Additional information about design of technical systems
No further data; see section 7.
Control parameters
Components with limit values that require monitoring at the workplace
Not required.
Additional information
The lists that were valid during the creation were used as basis.
Exposure controls
Personal protective equipment
General protective and hygienic measures
Wash hands before breaks and at the end of work.
Breathing equipment
Not required.
Protection of hands
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.
Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye protection
Not required.
Information on basic physicochemical properties
- Physical Stateneat solid
- ColorLight Yellow to Dark Yellow
- OdorCharacteristic
- Structural FormulaC16H13N3O3
- Molecular Weight295.3 g/mol
- Odor ThresholdNot determined.
- pHNot applicable.
- Melting point/Melting rangeUndetermined.
- Boiling point/Boiling range436.98°C (rough estimate)
- Flash point9℃
- Flammability (solid,gas)Product is not flammable.
- Decomposition temperatureNot determined.
- Ignition temperatureNot determined.
- Danger of explosionProduct does not present an explosion hazard.
- Explosion limitsLower: Not determined.
Upper: Not determined. - Vapor PressureNot applicable.
- Density1.1952 (rough estimate)
- Relative Density1.1952 (rough estimate)
- Vapor DensityNot applicable.
- Evaporation RateNot applicable.
- Solubility in / Miscibility withChloroform (Slightly), Methanol (Slightly)
- WaterNot determined.
- Partition coefficient (n-octanol/water)Not determined.
- DynamicNot applicable.
- KinematicNot applicable.
- SOLUBILITYACN; MeOH
- Other informationNo information available
Reactivity
No further relevant information available.
Chemical stability
Thermal decomposition / conditions to be avoided
No decomposition if used according to specifications.
Possibility of hazardous reactions
No dangerous reactions known.
Conditions to avoid
No further relevant information available.
Incompatible materials
strong oxidizing agents
Hazardous decomposition products
carbon oxides, nitrogen oxides
RTECS Number
DF2410000
Information on toxicological effects
Acute toxicity
LD/LC50 values that are relevant for classification:
| Route | Endpoint | Value |
|---|---|---|
| Oral | LD50 | 750 mg/kg (mouse) 970 mg/kg (rat) |
| Intraperitoneal | LD50 | 510 mg/kg (mouse) 970 mg/kg (rat) |
| Subcutaneous | LD50 | >5 g/kg (mouse) >1 g/kg (rat) |
Primary irritant effect
on the skin
No irritant effect.
on the eye
No irritating effect.
Sensitization
No sensitizing effects known.
Additional toxicological information
Carcinogenic categories
IARC (International Agency for Research on Cancer)
Substance is not listed.
NTP (National Toxicology Program)
Substance is not listed.
OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.
Toxicity
Aquatic toxicity
No further relevant information available.
Persistence and degradability
No further relevant information available.
Behavior in environmental systems
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Ecotoxical effects
Remark
Very toxic for fish
Additional ecological information
General notes
Water hazard class 2 (Self-assessment) hazardous for water
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
Very toxic for aquatic organisms
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
Very toxic for aquatic organisms
Results of PBT and vPvB assessment
PBT
Not applicable.
vPvB
Not applicable.
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
No further relevant information available.
Waste treatment methods
Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings
Recommendation
Disposal must be made according to official regulations.
UN-Number
DOT, IMDG, IATA UN3077
UN proper shipping name
DOT, IATA Environmentally hazardous substance, solid, n.o.s.
(Nimetazepam)
IMDG ENVIRONMENTALLY HAZARDOUS SUBSTANCE,
SOLID, N.O.S. (Nimetazepam)
(Nimetazepam)
IMDG ENVIRONMENTALLY HAZARDOUS SUBSTANCE,
SOLID, N.O.S. (Nimetazepam)
Transport hazard class(es)
DOTClass: 9 Miscellaneous dangerous substances and articles
Label: 9
IMDG, IATA
Label: 9
Class: 9 Miscellaneous dangerous substances and articles
Label: 9
Label: 9
Packing group
DOT, IMDG, IATA III
Environmental hazards
Marine pollutant: Symbol (fish and tree)
Special marking (IATA): Symbol (fish and tree)
Special marking (IATA): Symbol (fish and tree)
Marine pollutant
Symbol (fish and tree)
Special marking (IATA)
Symbol (fish and tree)
Special precautions for user
Warning: Miscellaneous dangerous substances and articles
Hazard identification number (Kemler code)
90
EMS Number
F-A,S-F
Stowage Category
A
Stowage Code
SW23 When transported in BK3 bulk container, see
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
Transport/Additional information
DOT:
Quantity limitations
On passenger aircraft/rail: 400 kg
On cargo aircraft only: 400 kg
On cargo aircraft only: 400 kg
IMDG:
Limited quantities (LQ)
5 kg
Excepted quantities (EQ)
Code: E1
Maximum net quantity per inner packaging: 30 g
Maximum net quantity per outer packaging: 1000 g
Maximum net quantity per inner packaging: 30 g
Maximum net quantity per outer packaging: 1000 g
IATA:
Remarks
When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
UN "Model Regulation"
UN 3077 ENVIRONMENTALLY HAZARDOUS
SUBSTANCE, SOLID, N.O.S. (NIMETAZEPAM), 9, III
SUBSTANCE, SOLID, N.O.S. (NIMETAZEPAM), 9, III
Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Sara
| Section 355 (extremely hazardous substances): | Substance is not listed. |
| Section 313 (Specific toxic chemical listings): | Substance is not listed. |
| TSCA (Toxic Substances Control Act): | Substance is not listed. |
| Hazardous Air Pollutants: | Substance is not listed. |
Proposition 65
| Chemicals known to cause cancer: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for females: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for males: | Substance is not listed. |
| Chemicals known to cause developmental toxicity: | Substance is not listed. |
Chemicals known to cause cancer
Substance is not listed.
Chemicals known to cause reproductive toxicity for females
Substance is not listed.
Chemicals known to cause reproductive toxicity for males
Substance is not listed.
Chemicals known to cause developmental toxicity
Substance is not listed.
Carcinogenic categories
| EPA (Environmental Protection Agency): | Substance is not listed. |
TLV (Threshold Limit Value)
Substance is not listed.
NIOSH-Ca (National Institute for Occupational Safety and Health)
Substance is not listed.
Chemical safety assessment
A Chemical Safety Assessment has not been carried out.
Abbreviations and acronyms
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute Toxicity - Oral 4: Acute toxicity – Category 4
Aquatic Acute 1: Hazardous to the aquatic environment - acute aquatic hazard – Category 1
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute Toxicity - Oral 4: Acute toxicity – Category 4
Aquatic Acute 1: Hazardous to the aquatic environment - acute aquatic hazard – Category 1
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.