Chemical Safety Data Sheet MSDS / SDS

Propargyl bromide

Revision Date:2026-03-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Propargyl bromide
  • CBnumber: CB3162370
  • CAS: 106-96-7
  • EINECS Number: 203-447-1
  • Synonyms: 3-Bromoprop-1-yne;3-BROMOPROPYNE

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Hazard statements
H225 Highly Flammable liquid and vapour
H301 Toxic if swalloed
H304 May be fatal if swallowed and enters airways
H314 Causes severe skin burns and eye damage
H335 May cause respiratory irritation
H373 May cause damage to organs through prolonged or repeated exposure

SECTION 3: Composition/information on ingredients

Substance

  • Product name: Propargyl bromide
  • Synonyms: 3-Bromoprop-1-yne;3-BROMOPROPYNE
  • CAS: 106-96-7
  • EC number: 203-447-1
  • MF: C3H3Br
  • MW: 118.96

SECTION 4: First aid measures

General advice

First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Call in physician.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

If swallowed

If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible. Pulmonary failure possible after aspiration of vomit. Do not attempt to neutralise.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11

Protection of first-aiders

For personal protection see section 8.

Notes to physician

No data available

SECTION 5: Firefighting measures

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards during fire fighting

Pay attention to flashback. Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air at ambient temperatures.

Hazardous combustion products

Carbon oxides Hydrogen bromide gas

Specific extinguishing methods

Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

Special protective equipment for fire-fighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

NFPA 704

3
3
4
HEALTH 3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE 3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
REACT 4 Readily capable of detonation or explosive decomposition at normal temperatures and pressures (e.g. nitroglycerin,chlorine dioxide, nitrogen triiodide)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material . Dispose of properly. Clean up affected area.

SECTION 7: Handling and storage

Handling

Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge.
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Avoidance of contact
Mercury/mercury oxides. Silver/silver oxides Peroxides

Storage

Further information on storage conditions
Keep container tightly closed in a dry and wellventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.
Storage class
3, Flammable liquids
Recommended storage temperature
2 - 8 °C
Further information on storage stability
Light sensitive.

SECTION 8: Exposure controls/personal protection

Ingredients with workplace control parameters

Biological occupational exposure limits (after exposure has ended) after exposure ceases)

Engineering measures

No data available

Personal protective equipment

Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Tightly fitting safety goggles
Skin and body protection
Flame retardant antistatic protective clothing.
Hand protection
Remarks
required
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical stateLiquid
  • SolubilityChloroform, Methanol (Slightly)
  • Appearanceliquid
  • ColorColorless - Yellow
  • OdorNo data available
  • Odor ThresholdNo data available
  • pHNo data available
  • Melting point/ rangeNo data available
  • Boiling point/boiling range97 °C
  • Flash point18 °C
    Method: closed cup
  • Evaporation rateNo data available
  • Flammability (solid, gas)No data available
  • Flammability (liquids)No data available
  • Burning rateNo data available
  • Upper explosion limit / Upper flammability limitNo data available
  • Lower explosion limit / Lower flammability limitNo data available
  • Vapor pressureNo data available
  • Relative vapor densityNo data available
  • Relative density1.38 g/mL at 20 °C
  • Density1.38 g/mL (20 °C)
  • Water solubilityMiscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.
  • Partition coefficient: n-octanol/waterNo data available
  • Autoignition temperatureNo data available
  • Decomposition temperatureNo data available
  • Viscosity, dynamicNo data available
  • Viscosity, kinematicNo data available
  • Flow timeNo data available
  • Explosive propertiesNot classified as explosive.
  • Oxidizing propertiesnone
  • Molecular weight118.96 g/mol
  • Particle characteristics Particle sizeNo data available

SECTION 10: Stability and reactivity

Reactivity

Vapors may form explosive mixture with air.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Contains the following stabilizer(s):

Magnesium oxide (0.3 %)

Possibility of hazardous reactions

No data available

Conditions to avoid

Heat. Warming.

Incompatible materials

Mercury/mercury oxides. Silver/silver oxides Peroxides

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Mixture Acute toxicity
Acute toxicity estimate Oral - 66.25 mg/kg (Calculation method)
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Acute toxicity estimate Inhalation - 4 h - > 40 mg/l - vapor(Calculation method)
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Remarks: Mixture causes burns.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Risk of blindness!
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Suspected of damaging the unborn child.
Suspected of damaging fertility.
Specific target organ toxicity - single exposure
Mixture may cause respiratory irritation.
Mixture may cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
Mixture may cause damage to organs through prolonged or repeated exposure.
- Central nervous system
Aspiration hazard
Aspiration hazard, Aspiration may cause pulmonary edema and pneumonitis.

11.2 Additional Information

Headache
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components 3-bromo-1-propyne
Acute toxicity
LD50 Oral - Rat - 53 mg/kg
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Remarks: (RTECS)
Oral: absorption
Symptoms: mucosal irritations, Cough, Shortness of breath, Inhalation may lead to the formation of oedemas in the respiratory tract., Possible damag- es:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause respiratory irritation.
Acute oral toxicity - If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Acute inhalation toxicity - mucosal irritations, Cough, Shortness of breath,
Inhalation may lead to the formation of oedemas in the respiratory tract.,
Possible damages:, damage of respiratory tract
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Toluene Acute toxicity
LD50 Oral - Rat - male - 5,580 mg/kg (Directive 67/548/EEC, Annex V, B.1.)
LC50 Inhalation - Rat - male - 4 h - 25.7 mg/l - vapor (OECD Test Guideline 403)
LD50 Dermal - Rabbit - male - > 5,000 mg/kg
Remarks: (ECHA)
Skin corrosion/irritation
Skin - Rabbit
Result: irritating - 4 h (Regulation (EC) No. 440/2008, Annex, B.4)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (Regulation (EC) No. 440/2008, Annex, B.6)
Germ cell mutagenicity
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Species: Rat - Bone marrow
Result: negative
Remarks: (ECHA)
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Suspected of damaging the unborn child.
Specific target organ toxicity - single exposure
Inhalation - May cause drowsiness or dizziness. - Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Specific target organ toxicity - repeated exposure
Inhalation - May cause damage to organs through prolonged or repeated exposure.
- Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Aspiration hazard
Aspiration may cause pulmonary edema and pneumonitis.

SECTION 12: Ecological information

Ecotoxicity

Components:

Toluene:

Toxicity to fish
LC50 (Oncorhynchus kisutch (coho salmon)): 5.5 mg/l End point: mortality Exposure time: 96 h Test Type: flow-through test Analytical monitoring: yes Remarks: (ECHA)
Toxicity to daphnia and other aquatic invertebrates
EC50 (Ceriodaphnia dubia (water flea)): 3.78 mg/l End point: mortality Exposure time: 48 h Analytical monitoring: yes Method: US-EPA
Toxicity to fish (Chronic toxicity)
NOEC (Oncorhynchus kisutch (coho salmon)): 1.39 mg/l End point: Growth inhibition Exposure time: 40 d Test Type: flow-through test Analytical monitoring: yes Remarks: (ECHA)
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
NOEC (Ceriodaphnia dubia (water flea)): 0.74 mg/l End point: reproduction rate Exposure time: 7 d Analytical monitoring: yes Method: US-EPA
Toxicity to microorganisms
EC50 (Bacteria): 84 mg/l Exposure time: 24 h Test Type: static test Remarks: (ECHA)

Persistence and degradability

Components:

Toluene:

Biodegradability
aerobic Result: Readily biodegradable. Biodegradation: 86 % Exposure time: 20 d Remarks: (IUCLID)

Bioaccumulative potential

Components:

Toluene:

Bioaccumulation
Species: Leuciscus idus (Golden orfe) Bioconcentration factor (BCF): 90 Exposure time: 3 d Concentration: 0.05 mg/l
Partition coefficient: noctanol/water
log Pow: 2.73 (20 °C) pH: 7 Remarks: Bioaccumulation is not expected.

Mobility in soil

No data available

Other adverse effects

Components:

3-bromo-1-propyne:

Additional ecological information
Biological effects: Forms toxic and corrosive mixtures with water even if diluted. Further information on ecology Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

Disposal methods

Waste from residues
Offer surplus and non-recyclable solutions to a licensed disposal company.

SECTION 14: Transport information

International Regulations

IATA-DGR

UN/ID No. : UN 2345
Proper shipping name : 3-Bromopropyne
Class : 3
Packing group : II
Labels : Class 3 - Flammable liquids
Packing instruction (cargo aircraft) : 364
Packing instruction (passenger aircraft) : 353

IMDG-Code

UN number : UN 2345
Proper shipping name : 3-BROMOPROPYNE
Class : 3
Packing group : II
Labels : 3
EmS Code : F-E, S-D
Marine pollutant : no

Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

Not applicable for product as supplied.
National regulation GB 6944/12268
UN number : UN 2345
Proper shipping name : 3-BROMOPROPYNE
Class : 3
Packing group : II
Labels : 3

Special precautions for user

The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.

SECTION 15: Regulatory information

National regulatory information

Law on the Prevention and Control of Occupational Diseases

Regulations on Safety Management of Hazardous Chemicals

Catalogue of Hazardous Chemicals

Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)

No. / Code Chemical name / Category Threshold quantity

W5.3 Flammable liquids 1,000 t

Hazardous Chemicals for Priority Management

Not applicable under SAWS

Catalogue of Specially Controlled Hazardous

Not listed Chemicals

List of Explosive Precursors

Not listed

Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals

China Severely Restricted Toxic Chemicals for Import and Export

Not applicable

Regulation on the Administration of Precursor Chemicals

Catalogue and Classification of Precursor Chemicals

Not listed

Regulations on the Administration of Controlled Chemicals

List of Controlled Chemicals

Not listed

Regulations of Ozone Depleting Substances Management

List of Controlled Ozone Depleting Substances

Not listed

List of Controlled Ozone Depleting Substances Import and Export

Not listed

Environmental Protection Law

List of Priority Controlled Chemicals

Listed

List of Key Controlled New Pollutants

Not listed

SECTION 16: Other information

Full text of other abbreviations

ACGIH
USA. ACGIH Threshold Limit Values (TLV)
ACGIH BEI
ACGIH - Biological Exposure Indices (BEI)
CN BEI
China. Biological Occupational Exposure Indices
GBZ 2.1-2007
Occupational exposure limits for hazardous agents in the workplace - Chemical hazardous agents.
ACGIH / TWA
8-hour, time-weighted average
GBZ 2.1-2007 / PC-TWA
Permissible concentration - time weighted average
GBZ 2.1-2007 / PC-STEL AIIC - Australian Invent Transport by Land of Bra bw - Body weight; CMR Standard of the German List (Canada); ECx - Conc associated with x% respo Chemical Substances (Jap response; ERG - Emerge GLP - Good Laboratory P cer; IATA - International Construction and Equipm Half maximal inhibitory c tion; IECSC - Inventory o tional Maritime Dangerou Industrial Safety and H Standardization; KECI - K tration to 50 % of a test (Median Lethal Dose); MA lution from Ships; n.o.s. No Observed (Adverse) E fect Level; NOELR - No Norm; NTP - National Toxi icals; OECD - Organizatio fice of Chemical Safety a and Toxic substance; PIC stances; (Q)SAR - (Quant (EC) No 1907/2006 of th Registration, Evaluation, Accelerating Decompositi Chemical Substance Inve Thailand Existing Chemica States); UN - United Nat Transport of Dangerous WHMIS - Workplace Hazar
Permissible concentration - short term exposure limit ry of Industrial Chemicals
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonized System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organization
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC fect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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