11.1 Information on toxicological effects
Mixture Acute toxicity
Acute toxicity estimate Oral - 66.25 mg/kg (Calculation method)
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Acute toxicity estimate Inhalation - 4 h - > 40 mg/l - vapor(Calculation method)
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Remarks: Mixture causes burns.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Risk of blindness!
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Suspected of damaging the unborn child.
Suspected of damaging fertility.
Specific target organ toxicity - single exposure
Mixture may cause respiratory irritation.
Mixture may cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
Mixture may cause damage to organs through prolonged or repeated exposure.
- Central nervous system
Aspiration hazard
Aspiration hazard, Aspiration may cause pulmonary edema and pneumonitis.
11.2 Additional Information
Headache
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components 3-bromo-1-propyne
Acute toxicity
LD50 Oral - Rat - 53 mg/kg
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Remarks: (RTECS)
Oral: absorption
Symptoms: mucosal irritations, Cough, Shortness of breath, Inhalation may lead to the formation of oedemas in the respiratory tract., Possible damag- es:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause respiratory irritation.
Acute oral toxicity - If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Acute inhalation toxicity - mucosal irritations, Cough, Shortness of breath,
Inhalation may lead to the formation of oedemas in the respiratory tract.,
Possible damages:, damage of respiratory tract
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Toluene Acute toxicity
LD50 Oral - Rat - male - 5,580 mg/kg (Directive 67/548/EEC, Annex V, B.1.)
LC50 Inhalation - Rat - male - 4 h - 25.7 mg/l - vapor (OECD Test Guideline 403)
LD50 Dermal - Rabbit - male - > 5,000 mg/kg
Remarks: (ECHA)
Skin corrosion/irritation
Skin - Rabbit
Result: irritating - 4 h (Regulation (EC) No. 440/2008, Annex, B.4)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (Regulation (EC) No. 440/2008, Annex, B.6)
Germ cell mutagenicity
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Species: Rat - Bone marrow
Result: negative
Remarks: (ECHA)
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Suspected of damaging the unborn child.
Specific target organ toxicity - single exposure
Inhalation - May cause drowsiness or dizziness. - Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Specific target organ toxicity - repeated exposure
Inhalation - May cause damage to organs through prolonged or repeated exposure.
- Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Aspiration hazard
Aspiration may cause pulmonary edema and pneumonitis.