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Chemical Properties Uses
Nitroglycerin structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Nitroglycerin Properties

Melting point:
2.8°; mp 13.5°
Boiling point:
368.78°C (rough estimate)
d1515 1.599; d44 1.6144; d415 1.6009; d425 1.5918
refractive index 
nD15 1.474
Flash point:
storage temp. 
Miscible with acetone and with anhydrous ethanol
Water Solubility 
1.25g/L(25 ºC)
Exposure limits
TLV-TWA skin 0.05 ppm (0.5 mg/m3) (ACGIH), 0.2 ppm (MSHA, OSHA, and NIOSH).
CAS DataBase Reference
55-63-0(CAS DataBase Reference)
EWG's Food Scores
NCI Dictionary of Cancer Terms
NCI Drug Dictionary
ATC code
NIST Chemistry Reference
1,2,3-Propanetriol, trinitrate(55-63-0)
EPA Substance Registry System
Nitroglycerin (55-63-0)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H225-H302+H312+H332-H319
Precautionary statements  P210-P370+P378-P403+P235-P280-P305+P351+P338
Hazard Codes  E,T+,N,Xn,T
Risk Statements  11-51/53-33-26/27/28-3-36-20/21/22-23/24/25
Safety Statements  7-16-61-45-36/37-35-33-26
RIDADR  1993
WGK Germany  3
HazardClass  1.1A
PackingGroup  I
HS Code  2920900002
Toxicity LD50 oral in rabbit: 1607mg/kg
NFPA 704
2 4

Nitroglycerin price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T-002 Trinitroglycerin solution 1000μg/mL in acetonitrile, ampule of 1mL, certified reference material 55-63-0 002-1ml $39.3 2020-08-18 Buy
Sigma-Aldrich T-002 Trinitroglycerin solution 1000?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? 55-63-0 1 mL $40.6 2021-03-22 Buy
Sigma-Aldrich T-021 Trinitroglycerin solution 1?% (w/w) in propylene glycol, ampule of 1?mL, certified reference material, Cerilliant? 55-63-0 1 mL $69.7 2021-03-22 Buy
Sigma-Aldrich S413143 NITRIN AldrichCPR 55-63-0 100MG $144 2021-03-22 Buy
Sigma-Aldrich G0400100 Glyceryl trinitrate solution European Pharmacopoeia (EP) Reference Standard 55-63-0 $190 2021-03-22 Buy

Nitroglycerin Chemical Properties,Uses,Production

Chemical Properties

Nitroglycerin is a pale yellow oily liquid and also available in the form of rhombic crystals. It is highly explosive. It is used in combination with ethylene glycol dinitrite in the manufacture of dynamites. It is slightly soluble in water and miscible with acetone, ether, benzene, and other organic solvents. Nitroglycerin is incompatible with strong acids, such as hydrochloric acid, sulphuric acid, and nitric acid, and also with ozone and causes violent reactions. Nitroglycerin is a powerful explosive in its pure form and very sensitive to mechanical shock, heat, or UV radiation.


Glyceryl trinitrate (GTN; nitroglycerin) is a representative compound from the organic nitrate ester family. Introduced in 1879, it has been used as a therapeutic agent in the treatment of angina pectoris. In the later part of the nineteenth century, the explosive property of nitroglycerin was discovered, and it then became the active component of dynamite. Glyceryl trinitrate, ethylene glycol dinitrate, and other nitrate esters are commonly used in military and mining explosives. In preparing dynamite, these nitrate esters are absorbed in a dope of oxidizing salts and various inert fillers.


Nitroglycerin is an oily, poisonous, clear to pale yellow, explosive liquid.Nitroglycerin is made by nitrating glycerol. Early industrial processes used a batch process in which glycerol was added to a mixture with approximately equal volumes of nitric acid and sulfuric acid.The sulfuric acid serves to ionize the nitric acid and removes water formed in the nitration process.

Chemical Properties

Nitroglycerin is a pale yellow liquid or crystalline solid (below 13℃).

Chemical Properties

Clear, colourless or slightly yellow solution


It was first prepared in 1846 by the Italian chemist Ascanio Sobrero (1812–1888), who nitrated glycerol using a mixture of nitric acid and sulfuric acid. Sobrero, who was injured in an explosion doing his research, realized the compound’s danger and abandoned work on nitroglycerin. Twenty years after Sobrero’s discovery, Alfred Nobel (1833–1896) developed its use commercially. Nobel mixed nitroglycerin with other substances, searching for a safe way to transport it and make it less sensitive to heat and pressure.
nitroglycerin when it was first marketed,and Nobel continued to experiment with methods to make nitroglycerin safer.One of these was mixing nitroglycerin with materials to make a solid form of nitroglycerin. Nobel discovered that when nitroglycerin was mixed with a silica-based diatomaceous earth material called kieselguhr,a relatively stable product resulted.The mixture produced a paste that Nobel could pack into cardboard tubes;these could then be inserted into holes drilled into rock structures and detonated.In 1867,Nobel patented his mixture and called it dynamite,a name derived from the Greek word dunamis, meaning power.Nobel also perfected a blasting cap made from mercury fulminate (Hg(ONC)2) and potassium chlorate (KClO3) to detonate the nitroglycerin.


Vasodilator (coronary) Minitran (3M Pharmaceuticals); Nitro-Bid (Sanofi Aventis); Nitro-Dur (Key); Nitrol (Rorer); Nitrolingual (Pohl Boskamp); Nitrostat (Pfizer); Transderm-Nitro (Novartis).


Nitroglycerin has medicinal use as a vasodilator. The main medical use of nitroglycerin is to treat angina pectoris. Nitroglycerin was first used to treat this condition in the late 19th century. It is prescribed today in various forms (tablet, ointment, patches, and injection) for patients who suffer from angina pectoris. Nitroglycerin is marketed under various trade names: Nitro-Dur, Nitrostat, Nitrospan, Nitro-Bid, and Tridil. When used in medications, the name glyceryl trinitrate is often used instead of nitroglycerin.


Nitroglycerin is an explosive agent contained in dynamite and an antianginal and vasodilator treatment. It is a well-known irritant in dynamite manufacturers. It can also cause allergic reactions in employees of manufacturers of explosives, or in the pharmaceutical industries. Nitroglycerin can cross react with isosorbide dinitrate.


Nitroglycerin (also isosorbide nitrate) relaxes isolated strips of human corpus cavernosum. Its mechanism involves the stimulation of guanylate cyclase. Clinically, nitroglycerin has been of limited use in the treatment of ED.

Production Methods

Nitroglycerin is made by nitrating glycerol.Early industrial processes used a batch processin which glycerol was added to a mixture with approximately equal volumes of nitric acidand sulfuric acid.The sulfuric acid serves to ionize the nitric acid and removes water formedin the nitration process.Removing the water formed in nitration increases the yield of nitroglycerin.Acids and water must be removed from the desired nitroglycerin through a washingprocess. The production of nitroglycerin is highly exothermic,and it is important to keepthe temperature below room temperature to prevent an explosion. Early production methodsused cooling coils in the nitration vessels to regulate the temperature.During the latter halfof the 20th century, safer continuous production methods replaced batch processes.In thesemethods much smaller reactors are required,as glycerol is reacted with the acids.


A highly explosive substance used in dynamite. It is obtained by treating glycerol (1,2,3-trihydroxypropane) with a mixture of concentrated nitric and sulfuric acids. It is not a nitro compound, but a nitrate ester CH2(NO3)CH(NO3)CH2(NO3).


ChEBI: A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Synthesis Reference(s)

Tetrahedron, 49, p. 7037, 1993 DOI: 10.1016/S0040-4020(01)87978-3

General Description

Glyceryl trinitrate is the trinitrate ester ofglycerol and is listed as available in tablet form in the USP.It is prepared by carefully adding glycerin to a mixture of nitricand fuming sulfuric acids. This reaction is exothermic,and the reaction mixture must be cooled to between 10°Cand 20°C.The ester is a colorless oil, with a sweet, burning taste. Itis only slightly soluble in water, but it is soluble in organicsolvents.

General Description

Colorless to pale-yellow, viscous liquid or solid (below 56°F). (Note: An explosive ingredient in dynamite (20-40%) with ethylene glycol dinitrate (80-60%).).

Air & Water Reactions

Highly flammable.

Reactivity Profile

Nitroalkanes, such as NITROGLYCERIN, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. Nitroalkanes are milder oxidizing agents, but still react violently with reducing agents at higher temperature and pressures. Nitroalkanes react with inorganic bases to form explosive salts. The presence of metal oxides increases the thermal sensitivity of nitroalkanes. Nitroalkanes with more than one nitro group are generally explosive. Nitroalkanes are insoluble in water. Flammable/combustible material. May be ignited by heat, sparks or flames. Nitroglycerin is incompatible with the following: Heat, ozone, shock, acids. Note: An OSHA Class A Explosive (1910.109). .


Severe explosion risk, highly sensitive to shock and heat. Toxic by ingestion, inhalation, and skin absorption. Toxic by skin absorption. Vasodilator.

Health Hazard

Severe acute poisoning may result from ingestion of nitroglycerine or inhalation of its dust. The acute toxic symptoms include headache, nausea, vomiting, abdominal pain, tremor, dyspnea, paralysis, and convulsions. In addition, methemoglobinemia and cyanosis may occur. Ingestion of a relatively smallamount, 1.5-2.0 g, could be fatal to humans. Inhalation of its vapors or dust at 0.3 mg/m3 concentration in air produced an immediate fall in blood pressure and headache in human volunteers (ACGIH 1986). Chronic poisoning may produce headache and hallucination.
LD50 value, oral (rats): 105 mg/kg.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Contact allergens

Nitroglycerin is an explosive agent contained in dynamite and an antianginal and vasodilator treatment available in systemic and topical forms. It is a well known irritant agent in dynamite manufacture. It can also cause allergic reactions in employees of explosives manufacturers and in the pharmaceutical industry. Transdermal systems are the main source of iatrogenic sensitization. Nitroglycerin can cross-react with isosorbide dinitrate.

Mechanism of action

Nitroglycerine reduces the load on the heart by dilating peripheral veins, reducing the myocardial need for oxygen, and facilitating redistribution of coronary blood flow in the region of the myocardium with reduced blood flow.

Clinical Use

Nitroglycerin is used extensively as an explosive in dynamite.A solution of the ester, if spilled or allowed to evaporate,will leave a residue of nitroglycerin. To prevent anexplosion of the residue, the ester must be decomposed byadding alkali. Even so, the material dispensed is so dilutethat the risk of explosions does not exist. It has a strong vasodilatingaction and, because it is absorbed through theskin, is prone to cause headaches among workers associatedwith its manufacture. This transdermal penetration is whynitroglycerin is useful in a patch formulation. In medicine, ithas the action typical of nitrites, but its action develops moreslowly and is of longer duration. Of all the known coronaryvasodilatory drugs, nitroglycerin is the only one capable ofstimulating the production of coronary collateral circulationand the only one able to prevent experimental myocardialinfarction by coronary occlusion.

Side effects

Vascular headache, postural hypotension, and reflex tachycardia are common side effects of organic nitrate therapy. Fortunately, tolerance to nitrate-induced headache develops after a few days of therapy. Postural hypotension and tachycardia can be minimized by proper dosage adjustment and by instructing the patient to sit down when taking rapidly acting preparations. An effective dose of nitrate usually produces a fall in upright systolic blood pressure of 10 mm Hg and a reflex rise in heart rate of 10 beats per minute. Larger changes than these should be avoided, because a reduction in myocardial perfusion and an increase in cardiac oxygen requirements may actually exacerbate the angina.
Since nitrite ions oxidize the iron atoms of hemoglobin and convert it to methemoglobin, there may be a loss in oxygen delivery to tissues. While methemoglobinemia does not follow therapeutic doses of organic nitrates, it can be observed after overdosage or accidental poisoning.

Safety Profile

Human poison by an unspecified route. Poison experimentally by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. A skin irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. It can cause respiratory difficulties and death due to respiratory paralysis by ingestion. The acute symptoms of nitroglycerin poisoning are headaches, nausea, vomiting, abdominal cramps, convulsions, methemoglobinemia, circulatory collapse and reduced blood pressure, excitement, vertigo, fainting, respiratory rales, and cyanosis. Toxic effects may occur by ingestion, inhalation of dust, or absorption through intact skin. Human systemic effects by intravenous route: encephalitis, miosis, corneal damage. Used as a vasodilator and as an explosive. A very dangerous fire hazard when exposed to heat, flame, or by spontaneous chemical reaction. A severe explosion hazard when shocked or exposed to 03 , heat, or flame. Nitroglycerin is a powerful explosive, very sensitive to mechanical shock, heat, or UV radiation. Small quantities of it can readily be detonated by a hammer blow on a hard surface, particularly when it has been absorbed in filter paper. It explodes when heated to 215°C. Frozen nitroglycerin is somewhat less sensitive than the liquid. However, a half-thawed or partially thawed mixture is more sensitive than either one. When heated to decomposition it emits toxic fumes of NOx.

Chemical Synthesis

Nitroglycerine, 1,2,3-propantrioltrinitrate (19.1.1), is synthesized by nitrating glycerol with nitric acid.

Potential Exposure

An explosive ingredient in dynamite (20-40%) with ethylene glycol dinitrate (80-60%). It is also used in making other explosives, rocket propellants; and medicine (vasodilator).


Nitroglycerin is a lipid-soluble substance that is rapidly absorbed across the sublingual or buccal mucosa. Its onset of action occurs within 2 to 5 minutes, with maximal effects observed at 3 to 10 minutes. Little residual activity remains 20 to 30 minutes after sublingual administration. The plasma half-life of nitroglycerin, given sublingually or by spray, is estimated to be 1 to 3 minutes. Nitroglycerin and other organic nitrate esters undergo first-pass metabolism and are rapidly metabolized in the liver by the enzyme glutathione organic nitrate reductase.


UN1204 Nitroglycerin solution in alcohol with not .1% nitroglycerin, Hazard Class: 3; Labels: 3-Flammable liquid. UN3064 Nitroglycerin, solution in alcohol with .1% but not .5% nitroglycerin, Hazard Class: 3; Labels: 3-Flammable liquid. UN0143 Nitroglycerin, desensitized with not ,40% nonvolatile, water-insoluble phlegmatizer, by mass. It falls in Hazard Class 1.1D (subsidiary hazard: 6.1).


Heat, ozone, shock, acids. An OSHA Class A Explosive (1910.109). Heating may cause violent combustion or explosion. May explosively decompose on shock, friction, or concussion. Reacts with ozone causing explosion hazard.

Waste Disposal

Do not wash into sewer. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Nitroglycerin Preparation Products And Raw materials

Raw materials

Preparation Products

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