Quinoline
Product identifier
- Product name: Quinoline
- CBnumber: CB2331254
- CAS: 91-22-5
- EINECS Number: 202-051-6
- Synonyms: Quinoline,quinolin
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: Quinoline
- Synonyms: Quinoline,quinolin
- CAS: 91-22-5
- EC number: 202-051-6
- MF: C9H7N
- MW: 129.16
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Nitrogen oxides (NOx) Combustible.
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
No data available
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Avoid exposure - obtain special instructions before use. Advice on safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.
Hygiene measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store in cool place.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentFace shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: butyl-rubber
Minimum layer thickness: 0,3 mm Break through time: 480 min
Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)
Splash contact Material: butyl-rubber
Minimum layer thickness: 0,3 mm Break through time: 480 min
Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Information on basic physicochemical properties
- Appearancelight yellow clear, liquid
- Odourpungent
- Odour ThresholdNo data available
- pH7,3 at 5 g/l at 20 °C
- Melting point/freezing pointMelting point/range: -17 - -13 °C - lit.
- Initial boiling point and boiling range113 - 114 °C at 15 hPa - lit. 237 °C - lit.
- Flash point101 °C - closed cup
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limits Upper explosion limit: 7 %(V) Lower explosion limit: 1,2 %(V)
- Vapour pressure 0,09 hPa at 20 °C
- Vapour density 4,46 - (Air = 1.0)
- Relative density1,093 g/cm3 at 25 °C - lit. No data available
- Water solubility6,11 g/l at 20 °C - soluble
- Partition coefficient: n-octanol/waterlog Pow: 2,03 - Bioaccumulation is not expected., (Lit.)
- Autoignition temperature480 °C
- Decomposition temperatureNo data available
- ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
Surface tension 45 mN/m at 20 °C
Dissociation constant 4,9
Relative vapor density
4,46 - (Air = 1.0)
Reactivity
No data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
No data available
Incompatible materials
Strong oxidizing agents, Strong acids
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicity(OECD Test Guideline 401)
Symptoms: Nausea, Vomiting, Gastrointestinal disturbance Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - 1.377 mg/kg (OECD Test Guideline 402)
Result: irritating - 24 h (Draize Test) Remarks: (ECHA)
Result: Severe irritations - 24 h Remarks: (ECHA)
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Result: Positive results were obtained in some in vitro tests. Remarks: (ECHA)
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: Mutagenicity (Salmonella typhimurium - reverse mutation assay) Result: Positive results were obtained in some in vitro tests.
Remarks: (ECHA)
Test Type: sister chromatid exchange assay Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Result: Positive results were obtained in some in vitro tests. Remarks: (ECHA)
Test Type: In vitro mammalian cell gene mutation test Test system: Mouse lymphoma test
Metabolic activation: without metabolic activation Result: positive
Remarks: (ECHA)
Test Type: Micronucleus test Species: Mouse
Cell type: Bone marrow
Application Route: Intraperitoneal injection
Result: positive Remarks: (ECHA)
Toxicity
Persistence and degradability
Biodegradability Result: 100 % - Readily biodegradable.
(OECD Test Guideline 301D)
Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 6 Weeks
at 25 °C - 0,8 mg/l(quinoline)
Mobility in soil
No data available
Bioconcentration factor (BCF): 1,6 - 2,5 Elimination: yes
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Toxic to aquatic life with long lasting effects. Discharge into the environment must be avoided.
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.
IncompatibilitiesReacts, possibly violently, with strong oxidants, strong acids; perchromates, nitrogen tetroxide; and maleic anhydride. Keep away from moisture, steam, and light. Contact with hydrogen peroxide may cause explosion. Unpredictably violent, this substance has been the source of various plant accidents.
Waste DisposalDissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Contaminated packaging
Dispose of as unused product.
UN number
UN proper shipping name
Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
Packaging group
ADR/RID: III IMDG: III IATA: III
Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.