Chemical Safety Data Sheet MSDS / SDS

Tolylene-2,4-diisocyanate

Revision Date:2024-01-06Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Tolylene-2,4-diisocyanate
CBnumber: CB6170855
CAS: 584-84-9
EINECS Number: 209-544-5
Synonyms: TDI,TDI-80

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P284 Wear respiratory protection.

P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P320 Specific treatment is urgent (see … on this label).

P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Hazard statements

H315 Causes skin irritation

H317 May cause an allergic skin reaction

H319 Causes serious eye irritation

H330 Fatal if inhaled

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

H412 Harmful to aquatic life with long lasting effects

H351 Suspected of causing cancer

H335 May cause respiratory irritation

Disposal

WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/toluene-diisocyanate

SECTION 3: Composition/information on ingredients

Substance

Product name: Tolylene-2,4-diisocyanate
Synonyms: TDI,TDI-80
CAS: 584-84-9
EC number: 209-544-5
MF: C9H6N2O2
MW: 174.16

SECTION 4: First aid measures

Description of first aid measures

General advice

Consult a physician. Show this material safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx)

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

No data available

NFPA 704

HEALTH	3	Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE	1	Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT	2	Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.

For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.

Hygiene measures

Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: butyl-rubber

Minimum layer thickness: 0,3 mm Break through time: 480 min

Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 240 min

Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Exposure limits

TLV-TWA 0.0355 mg/m³ (0.005 ppm) (ACGIH and NIOSH); STEL or ceiling/10 min 0.142 mg/m³ (0.02 ppm) (ACGIH, NIOSH, and OSHA); IDLH 71 mg/m³ (10 ppm) (NIOSH).

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancecolorless clear, liquid
OdourNo data available
Odour ThresholdNo data available
pHNo data available
Melting point/freezing pointMelting point/range: 19,5 - 21,5 °C - lit.
Initial boiling point and boiling range 124 - 126 °C at 24 hPa - lit. 251 °C - lit.
Flash point132 °C - closed cup
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limits Upper explosion limit: 9,5 %(V) Lower explosion limit: 0,9 %(V)
Vapour pressure 0,04 hPa at 25 °C
Vapour density 6,01 - (Air = 1.0)
Relative density1.225
Water solubilityMiscible with ether, acetone, benzene, carbontetrachloride and chlorobenzene.
Partition coefficient: n-octanol/waterlog Pow: 3,43 at 22 °C
Autoignition temperatureNo data available
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: 2 mm2/s at 21 °C Viscosity, dynamic: No data available
Explosive propertiesNo data available
Oxidizing propertiesNo data available

Other safety information

Surface tension 25 mN/m at 25 °C

Relative vapor density

6,01 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

Heat.

Incompatible materials

Alcohols, Strong bases, Amines, acids, Strong oxidizing agents

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - male - 5.110 mg/kg (OECD Test Guideline 401)
Remarks: (in analogy to similar compounds)
The value is given in analogy to the following substances: m-tolylidene diisocyanate LC50 Inhalation - Rat - male and female - 4 h - 0,12 mg/l
(OECD Test Guideline 403)
Remarks: (in analogy to similar products)
LD50 Dermal - Rabbit - male and female - > 9.400 mg/kg (OECD Test Guideline 402)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: m-tolylidene diisocyanate

Skin corrosion/irritation

Skin - Rabbit
Result: Irritating to skin. - 24 h Remarks: (RTECS)
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Serious eye damage/eye irritation

Eyes - Rabbit
Result: Irritating to eyes. (Draize Test)
Remarks: (ECHA)
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Respiratory or skin sensitization

Remarks: (ECHA)
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
May cause allergy or asthma symptoms or breathing difficulties if inhaled. Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Germ cell mutagenicity

Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: positive
Test Type: In vivo micronucleus test Species: Rat
Application Route: Inhalation
Method: Mutagenicity (micronucleus test) Result: negative
Test Type: unscheduled DNA synthesis assay Species: Rat
Application Route: Inhalation Result: negative
Remarks: (ECHA)
Test Type: Micronucleus test Species: Mouse
Application Route: Inhalation Method: OECD Test Guideline 474 Result: negative

Carcinogenicity

No data available

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

Inhalation - May cause respiratory irritation. - Respiratory Tract
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Toxicity

Acute oral LD50 for rats 5,800 mg/kg, wild birds 100 mg/kg (quoted, RTECS, 1985).

SECTION 12: Ecological information

Toxicity

Toxicity to fish

static test LC50 - Oncorhynchus mykiss (rainbow trout) - 133 mg/l - 96 h

(OECD Test Guideline 203)

Remarks: (in analogy to similar products)

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - 12,5 mg/l - 48 h (OECD Test Guideline 202)

Remarks: (in analogy to similar products)

Toxicity to algae

EC50 - Skeletonema costatum (marine diatom) - 3.230 mg/l - 96 h (OECD Test Guideline 201)

Remarks: (in analogy to similar products)

Toxicity to bacteria

EC50 - activated sludge - > 100 mg/l - 3 h

(OECD Test Guideline 209)

Remarks: (in analogy to similar products)

Persistence and degradability

Biodegradability aerobic Biochemical oxygen demand - Exposure time 28 d Result: 0 % - Not biodegradable.

(OECD Test Guideline 302C)

Remarks: (in analogy to similar compounds)

Bioaccumulative potential

Bioaccumulation Cyprinus carpio (Carp) - 60 d

at 24,8 °C - 0,8 mg/l(4-methyl-m-phenylene diisocyanate)

Bioconcentration factor (BCF): 180 (OECD Test Guideline 305)

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

Harmful to aquatic life with long lasting effects.

SECTION 13: Disposal considerations

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company.

Incompatibilities

Contact with strong oxidizers may cause fires and explosions. Contact with water, acids, bases, and amines can lead to reactions that liberate heat and CO2 and cause violent foaming and spattering. TDI will attack some forms of plastic, rubber, and coatings.

Waste Disposal

Excess TDI and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: 2078 IMDG: 2078 IATA: 2078

UN proper shipping name

	ADR/RID: TOLUENE DIISOCYANATE IMDG: TOLUENE DIISOCYANATE
IATA: Toluene diisocyanate
14.3	Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1	IATA: 6.1
14.4	Packaging group ADR/RID: II IMDG: II	IATA: II
14.5	Environmental hazards ADR/RID: no IMDG Marine pollutant: no	IATA: no
14.6	Special precautions for user No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

EC Inventory:Listed.

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

SECTION 16: Other information

Abbreviations and acronyms

ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
CAS: Chemical Abstracts Service
EC50: Effective Concentration 50%
IATA: International Air Transportation Association
IMDG: International Maritime Dangerous Goods
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
STEL: Short term exposure limit
TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Technical toluene diisocyanate is either 100% 2,4- or a mixture of 2,4- and 2,6-isomers. TDI is a common name. CAS number of the mixture is 26471-62-5.Depending on the degree of exposure, periodic medical examination is suggested.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.The odour warning when the exposure limit value is exceeded is insufficient.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.