Chemical Safety Data Sheet MSDS / SDS


Revision Date:2024-05-11Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Trimethylamine
  • CBnumber: CB6332996
  • CAS: 75-50-3
  • EINECS Number: 200-875-0
  • Synonyms: Trimethylamine,Methylamine, N,N-dimethyl-

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

Classification of the substance or mixture

Gases under pressure: Liquefied gas

Flammable gases, Category 1A, Flammable gas

Skin irritation, Category 2

Serious eye damage, Category 1

Acute toxicity - Category 4, Inhalation

Specific target organ toxicity – single exposure, Category 3

Label elements

  • Signal wordDanger
Hazard statement(s)

H220 Extremely flammable gas

H224 Extremely flammable liquid and vapour

H225 Highly Flammable liquid and vapour

H280 Contains gas under pressure; may explode if heated

H302 Harmful if swallowed

H314 Causes severe skin burns and eye damage

H315 Causes skin irritation

H318 Causes serious eye damage

H332 Harmful if inhaled

H333 May be harmful if inhaled

H335 May cause respiratory irritation

H351 Suspected of causing cancer

H402 Harmful to aquatic life

H412 Harmful to aquatic life with long lasting effects

Precautionary statement(s)

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P310 Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405 Store locked up.

P403+P235 Store in a well-ventilated place. Keep cool.

P410+P403 Protect from sunlight. Store in a well-ventilated place.


P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.


P377 Leaking gas fire: Do not extinguish, unless leak can be stopped safely.

P381 In case of leakage, eliminate all ignition sources.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P317 Get medical help.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.


P410+P403 Protect from sunlight. Store in a well-ventilated place.

P403 Store in a well-ventilated place.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.


P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards

no data available

SECTION 3: Composition/information on ingredients


  • Product name: Trimethylamine
  • Synonyms: Trimethylamine,Methylamine, N,N-dimethyl-
  • CAS: 75-50-3
  • EC number: 200-875-0
  • MF: C3H9N
  • MW: 59.11

SECTION 4: First aid measures

Description of first aid measures

If inhaled

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Following skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

Following eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Following ingestion

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

Most important symptoms and effects, both acute and delayed

no data available

Indication of any immediate medical attention and special treatment needed

no data available

SECTION 5: Firefighting measures

Extinguishing media

Use dry chemical, carbon dioxide or alcohol-resistant foam.

Specific Hazards Arising from the Chemical

Extremely flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive.

Advice for firefighters

Use water in large amounts, alcohol-resistant foam, dry powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

NFPA 704

HEALTH 3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE 4 Will rapidly or completely vaporize at normal atmospheric pressure and temperature, or is readily dispersed in air and will burn readily. Includes pyrophoric substances. Flash point below room temperature at 22.8 °C (73 °F). (e.g. acetylene, propane, hydrogen gas)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Evacuate danger area! Consult an expert! Ventilation. Remove all ignition sources. Remove vapour with fine water spray. Personal protection: complete protective clothing including self-contained breathing apparatus.

Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

SECTION 7: Handling and storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Use non-sparking handtools. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Well closed. Separated from strong acids, oxidants, aluminium, copper, copper alloys, zinc, zinc alloys and mercury.

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

TLV: 5 ppm as TWA; 15 ppm as STEL.MAK: 4.9 mg/m3, 2 ppm; peak limitation category: I(2); pregnancy risk group: C

Biological limit values

no data available

Exposure controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures

Eye/face protection

Wear face shield or eye protection in combination with breathing protection.

Skin protection

Protective gloves. Protective clothing.

Respiratory protection

Use ventilation, local exhaust or breathing protection.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical stateLiquid
  • ColourColorless
  • Odour

    no data available

  • Melting point/freezing point


  • Boiling point or initial boiling point and boiling range


  • Flammability

    no data available

  • Lower and upper explosion limit/flammability limit11.6%
  • Flash point


  • Auto-ignition temperature


  • Decomposition temperature

    no data available

  • pHa strong base (pH 9.8)
  • Kinematic viscosity

    no data available

  • Solubilityvery soluble in water, slightly soluble in alcohol, ether, benzene, toluene, xylene, ethylbenzene, chloroform maximum allowable concentration: TLV 10 p.p.m. (24 mg/m3) and STEL of 15 p.p.m. (36 mg/m3) (ACGIH 1986)
  • Partition coefficient n-octanol/water


  • Vapour pressure430 mm Hg ( 25 °C)
  • Density and/or relative density

    0.63g/mLat 20°C(lit.)

  • Relative vapour density

    2.09 (vs air)

  • Particle characteristics

    no data available

SECTION 10: Stability and reactivity


no data available

Chemical stability

no data available

Possibility of hazardous reactions

The vapour is heavier than air and may travel along the ground; distant ignition possible.The substance is a medium strong base. Reacts violently with mercury and oxidants. This generates fire and explosion hazard. Attacks metals such as aluminium, copper, zinc, tin and their alloys.

Conditions to avoid

no data available

Incompatible materials

no data available

Hazardous decomposition products

no data available

SECTION 11: Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

Test Type: Ames test
Test system: Salmonella typhimurium TA100, TA1535, TA98, TA1537, Escherichia coli WP2 uvrA
Method: Guidelines for Screening Mutagenicity Testing of Chemicals(Chemical Substances Control Law of Japan) and OECD Test Guideline 471
Metabolic activation: with and without metabolic activation
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster lung (CHL/IU) cells
Method: Guidelines for Screening Mutagenicity Testing of Chemicals(Chemical Substances Control Law of Japan) and OECD Test Guideline 473
Metabolic activation: with and without metabolic activation
Result:Increase in structural chromosomal aberrations was observed in the test with the short-term treatment (-S9 and +S9).


no data available

Reproductive toxicity

no data available

STOT-single exposure

The substance is corrosive to the eyes and skin. The vapour is severely irritating to the respiratory tract. Corrosive on ingestion.

STOT-repeated exposure

no data available

Aspiration hazard

A harmful contamination of the air will be reached very quickly on evaporation of this substance at 20°C.

SECTION 12: Ecological information


  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

Persistence and degradability

no data available

Bioaccumulative potential

no data available

Mobility in soil

no data available

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: UN1297 (For reference only, please check.)

IMDG: UN1297 (For reference only, please check.)

IATA: UN1297 (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: TRIMETHYLAMINE, AQUEOUS SOLUTION, not more than 50% trimethylamine, by mass (For reference only, please check.)

IMDG: TRIMETHYLAMINE, AQUEOUS SOLUTION, not more than 50% trimethylamine, by mass (For reference only, please check.)

IATA: TRIMETHYLAMINE, AQUEOUS SOLUTION, not more than 50% trimethylamine, by mass (For reference only, please check.)

Transport hazard class(es)

ADR/RID: 3 (For reference only, please check.)

IMDG: 3 (For reference only, please check.)

IATA: 3 (For reference only, please check.)

Packing group, if applicable

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

Environmental hazards




Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)
EC Inventory
United States Toxic Substances Control Act (TSCA) Inventory
China Catalog of Hazardous chemicals 2015
New Zealand Inventory of Chemicals (NZIoC)
Vietnam National Chemical Inventory
Korea Existing Chemicals List (KECL)

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website:
  • HSDB - Hazardous Substances Data Bank, website:
  • IARC - International Agency for Research on Cancer, website:
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA - European Chemicals Agency, website:

Other Information

The toxicological data apply to solutions containing over 15% of trimethylamine.See ICSC 0206 Trimethylamine gas in a cylinder.


The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

Recommended Products
Diphenylcarbamyl chloride SDS 2-Chloro-N,N-diethylacetamide SDS N,N-Dimethylaminomethylferrocene SDS Tetradecyltrimethylammonium bromide SDS Trimethylamine N-oxide dihydrate SDS Dimethylcarbamoyl chloride SDS Diethylcarbamyl chloride SDS 1,4-Butanediol dimethacrylate SDS Trimethylamine hydrochloride SDS 1-(3,4-DIHYDRO-2-NAPHTHYL)PYRROLIDINE SDS