BTP2
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- ₹20090 - ₹89550
- Product name: BTP2
- CAS: 223499-30-7
- MF: C15H9F6N5OS
- MW: 421.32
- EINECS:
- MDL Number:MFCD00220976
- Synonyms:BTP2;N-[4-[3,5-BIS(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]PHENYL]-4-METHYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE;4-methyl-4μ-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide;YM-58483;CRAC Channel Inhibitor, BTP2;YM-58483(BTP2);BTP 2, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide;YM-5883
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberY4895
- Product descriptionYM-58483 ≥98% (HPLC)
- Packaging5MG
- Price₹20090
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberY4895
- Product descriptionYM-58483 ≥98% (HPLC)
- Packaging25MG
- Price₹89550
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | Y4895 | YM-58483 ≥98% (HPLC) | 5MG | ₹20090 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | Y4895 | YM-58483 ≥98% (HPLC) | 25MG | ₹89550 | 2022-06-14 | Buy |
Properties
Melting point :165-167 °C
Density :1.63±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :10.53±0.70(Predicted)
form :Solid
color :white to beige
InChI :1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
InChIKey :XPRZIORDEVHURQ-UHFFFAOYSA-N
SMILES :Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F
Density :1.63±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :10.53±0.70(Predicted)
form :Solid
color :white to beige
InChI :1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
InChIKey :XPRZIORDEVHURQ-UHFFFAOYSA-N
SMILES :Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F
Safety Information
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Description
Calcium release-activated calcium (CRAC) channels mediate sustained calcium influx in electrically non-excitable cells. CRAC channels are activated by the release of calcium from intracellular stores, as induced by inositol trisphosphate. CRAC channel activation is essential for the activation of leukocytes and the production of cytokines and inflammatory mediators. YM-58483 is a potent inhibitor of CRAC channels, blocking thapsigargin-induced sustained calcium influx, Th2 cytokine production, and NF-AT-driven promoter activity in T lymphocytes (IC50 = 100 nM). YM-58483 also inhibits lung interleukin-4 and cysteinyl leukotriene generation as well as airway eosinophil infiltration in animal models of asthma.More related product prices
371942-69-7 YM-53601 902589-96-2 YM 26734 YM155 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINERelated product price
- 902589-96-2
₹11506.98-46374.3 - YM 26734
₹13563.73-54547.18
Suppliers and manufacturers
A.J Chemicals
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Shanghai Acmec Biochemical Technology Co., Ltd.
