Decursin
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- ₹10045.6 - ₹40593.75
- Product name: Decursin
- CAS: 5928-25-6
- MF: C19H20O5
- MW: 328.36
- EINECS:
- MDL Number:MFCD00272154
- Synonyms:DECURSIN;DECURSINOL ANGELATE;(7S)-7,8-Dihydro-8,8-dimethyl-7-[(3-methyl-2-butenoyl)oxy]-2H,6H-benzo[1,2-b:5,4-b']dipyran-2-one;3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl ester;3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester;(7S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl 3-methyl-2-butenoate;(S)-(+)-decursin;Decursin ((+)-Decursin)
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0786
- Product descriptionDecursin ≥97% (HPLC)
- Packaging1MG
- Price₹10045.6
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0786
- Product descriptionDecursin ≥97% (HPLC)
- Packaging5MG
- Price₹40593.75
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0786 | Decursin ≥97% (HPLC) | 1MG | ₹10045.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0786 | Decursin ≥97% (HPLC) | 5MG | ₹40593.75 | 2022-06-14 | Buy |
Properties
Melting point :93-94℃
Boiling point :469.4±45.0 °C(Predicted)
Density :1.24
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear
form :powder
color :white to beige
biological source :Radix peucedani
optical activity :[α]/D +120 to +160°, c = 0.5 in chloroform-d
InChI :InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
InChIKey :CUKSFECWKQBVED-INIZCTEOSA-N
SMILES :C(O[C@@H]1C(C)(C)OC2=C(C1)C=C1C(=C2)OC(=O)C=C1)(=O)/C=C(/C)\C
Boiling point :469.4±45.0 °C(Predicted)
Density :1.24
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear
form :powder
color :white to beige
biological source :Radix peucedani
optical activity :[α]/D +120 to +160°, c = 0.5 in chloroform-d
InChI :InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
InChIKey :CUKSFECWKQBVED-INIZCTEOSA-N
SMILES :C(O[C@@H]1C(C)(C)OC2=C(C1)C=C1C(=C2)OC(=O)C=C1)(=O)/C=C(/C)\C
Safety Information
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Description
Decursin is a phytochemical originally isolated from A. gigas with diverse biological activities. It reduces the growth of B16/F10 murine melanoma cells, but not NIH-3T3 fibroblasts, via induction of apoptosis and increased caspase-3 activity when used at concentrations ranging from 40 to 100 μM. In vivo, decursin (10 mg/kg, i.p.) reduces tumor growth in a B16/F10 mouse xenograft model. Decursin inhibits RANKL-induced osteoclast differentiation and decreases fusion and migrations of pre-osteoclasts in vitro and prevents LPS-induced bone erosion in mice. In a mouse model of seizures induced by kainic acid , decursin (20 mg/kg) increases latency to the first electroencephalographic (EEG) discharge and attenuates the intensity and reduces the frequency of seizure discharges in the parietal cortex. Decursin inhibits tube formation and expression of VEGF receptor 2 (VEGFR2) in human retinal microvascular endothelial cells (HRMECs) and human umbilical vein endothelial cells (HUVECs) in vitro and reduces retinal expression of VEGFR2 and neovascularization in rats with diabetes induced by streptozotocin . It also reduces hepatic collagen expression, serum levels of ALT, AST, and ALP, and production of reactive oxygen species (ROS) in a mouse model of CCL4-induced liver fibrosis.Related product price
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