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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Antibiotics anticancer drugs >Epirubicin hydrochloride

Epirubicin hydrochloride

Epirubicin hydrochloride Structure
  • ₹5340 - ₹32300
  • Product name: Epirubicin hydrochloride
  • CAS: 56390-09-1
  • MF: C27H30ClNO11
  • MW: 579.9802
  • EINECS:260-145-2
  • MDL Number:MFCD00274554
  • Synonyms:4’-epi-adriamycinhydrochloride ;5,12-naphthacenedione,10-((3-amino-2,3,6-trideoxy-alpha-l-arabino-hexopyranosy ;8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-l)oxy)-hyd ;EPIRUBICIN HYDROCHLORIDE EP STANDARD;EpirubicinHc,LEp5,;Adrial;(8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, hydrochloride (1:1);5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
4 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)
  • SRL

Package

  • 5MG
  • 10MG
  • 25mg
  • ManufacturerSigma-Aldrich(India)
  • Product numberE9406
  • Product descriptionEpirubicin hydrochloride ≥90% (HPLC)
  • Packaging10MG
  • Price₹32300
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberE9406
  • Product descriptionEpirubicin hydrochloride ≥90% (HPLC)
  • Packaging5MG
  • Price₹11990
  • Updated2022-06-14
  • Buy
  • ManufacturerSRL
  • Product number97857
  • Product descriptionEpirubicin Hydrochloride (EPR.HCl), 97%
  • Packaging10mg
  • Price₹5340
  • Updated2022-05-26
  • Buy
  • ManufacturerSRL
  • Product number97857
  • Product descriptionEpirubicin Hydrochloride (EPR.HCl), 97%
  • Packaging25mg
  • Price₹10680
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) E9406 Epirubicin hydrochloride ≥90% (HPLC) 10MG ₹32300 2022-06-14 Buy
Sigma-Aldrich(India) E9406 Epirubicin hydrochloride ≥90% (HPLC) 5MG ₹11990 2022-06-14 Buy
SRL 97857 Epirubicin Hydrochloride (EPR.HCl), 97% 10mg ₹5340 2022-05-26 Buy
SRL 97857 Epirubicin Hydrochloride (EPR.HCl), 97% 25mg ₹10680 2022-05-26 Buy

Properties

Melting point :185°C dec.
alpha :D20 +274° (c = 0.01 in methanol)
RTECS :QI9295750
Flash point :443.8℃
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO to 100mM, or in ethanol to 10mM
form :powder
color :red to deep red
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChIKey :MWWSFMDVAYGXBV-UAOJCOQHSA-N
SMILES :C12=C(O)C3=C(C(=O)C4=C(C3=O)C=CC=C4OC)C(O)=C1[C@@]([H])(O[C@H]1O[C@@H](C)[C@H](O)[C@@H](N)C1)C[C@](O)(C(=O)CO)C2.Cl

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Epirubicin is a stereoisomer of the antitumor anthracycline doxorubicin that undergoes β-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin. Compared to doxorubicin, epirubicin is equally cytotoxic to HeLa cells (ID50s = 9 μM). When used either alone or in combination therapies, epirubicin has been shown to demonstrate high rates of complete or partial remission in various cancers including advanced ovary, lymphomas, breast, pancreas, gastric, hepatocellular carcinoma, head and neck tumors, and colorectal.

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