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ChemicalBook > Product Catalogue >Organic Chemistry >Carboxylic acids and derivatives >Acyclic carboxylic acid >Trifluoroacetic acid

Trifluoroacetic acid

Trifluoroacetic acid Structure
  • ₹1080 - ₹113940
  • Product name: Trifluoroacetic acid
  • CAS: 76-05-1
  • MF: C2HF3O2
  • MW: 114.02
  • EINECS:200-929-3
  • MDL Number:MFCD00004169
  • Synonyms:R3, TRIFLUOROACETIC ACID;RARECHEM AL BO 0421;TRIFLUOROACETIC ACID;TRIFLUOROACETLC ACID;IPC-PFFA-2;TRIFLUOROACETETIC ACID;Trifluoroaceticacidbiolgrmincolorlessliq;Trifluoroaceticacidmincolorlessliq
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Brand

  • ALFA India
  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • SRL
  • ottokemi

Package

  • 1ML
  • 4X2ML
  • 10X1ML
  • 50G
  • 50ML
  • 250ML
  • 1L
  • 2.5L
  • 2500ml
  • 25KG
  • 10AMP
  • 8082600521
  • 5X10AMP
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  • 5ML
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  • 4x500mL
  • 8082600121
  • 4x100mL
  • 500mL
  • 2500g
  • 2.5kg
  • 1AMP
  • ManufacturerALFA India
  • Product numberALF-A12198-22
  • Product descriptionTrifluoroacetic acid, 99%
  • Packaging100g
  • Price₹3263
  • Updated2022-05-26
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  • ManufacturerALFA India
  • Product numberALF-031771-22
  • Product descriptionTrifluoroacetic acid, 99.5+%
  • Packaging100g
  • Price₹6118
  • Updated2022-05-26
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  • ManufacturerALFA India
  • Product numberALF-044630-AE
  • Product descriptionTrifluoroacetic acid, HPLC Grade, 99.5+%
  • Packaging100mL
  • Price₹7422
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-A12198-36
  • Product descriptionTrifluoroacetic acid, 99%
  • Packaging500g
  • Price₹11517
  • Updated2022-05-26
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  • ManufacturerALFA India
  • Product numberALF-031771-36
  • Product descriptionTrifluoroacetic acid, 99.5+%
  • Packaging500g
  • Price₹13935
  • Updated2022-05-26
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  • ManufacturerALFA India
  • Product numberALF-044630-5Y
  • Product descriptionTrifluoroacetic acid, HPLC Grade, 99.5+%
  • Packaging4x100mL
  • Price₹27541
  • Updated2022-05-26
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  • ManufacturerALFA India
  • Product numberALF-031771-A4
  • Product descriptionTrifluoroacetic acid, 99.5+%
  • Packaging2.5kg
  • Price₹31248
  • Updated2022-05-26
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  • ManufacturerALFA India
  • Product numberALF-A12198-0E
  • Product descriptionTrifluoroacetic acid, 99%
  • Packaging2500g
  • Price₹31706
  • Updated2022-05-26
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  • ManufacturerALFA India
  • Product numberALF-044630-AP
  • Product descriptionTrifluoroacetic acid, HPLC Grade, 99.5+%
  • Packaging500mL
  • Price₹32688
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-044630-AY
  • Product descriptionTrifluoroacetic acid, HPLC Grade, 99.5+%
  • Packaging4x500mL
  • Price₹101802
  • Updated2022-05-26
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  • ManufacturerTCI Chemicals (India)
  • Product numberA5711
  • Product descriptionTrifluoroacetic Acid (ca. 0.5mol/L in Water) [Ion-Pair Reagent for LC-MS]
  • Packaging10ML
  • Price₹2000
  • Updated2022-05-26
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  • ManufacturerTCI Chemicals (India)
  • Product numberT0431
  • Product descriptionTrifluoroacetic Acid
  • Packaging25G
  • Price₹2000
  • Updated2022-05-26
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  • ManufacturerTCI Chemicals (India)
  • Product numberT0431
  • Product descriptionTrifluoroacetic Acid
  • Packaging100G
  • Price₹3600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberQ0053
  • Product descriptionTrifluoroacetic Acid [Sequenation Reagent]
  • Packaging25ML
  • Price₹6500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT0431
  • Product descriptionTrifluoroacetic Acid
  • Packaging500G
  • Price₹9600
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT6508
  • Product descriptionTrifluoroacetic acid ReagentPlus?, 99%
  • Packaging1AMP
  • Price₹2143.35
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ALFA India ALF-A12198-22 Trifluoroacetic acid, 99% 100g ₹3263 2022-05-26 Buy
ALFA India ALF-031771-22 Trifluoroacetic acid, 99.5+% 100g ₹6118 2022-05-26 Buy
ALFA India ALF-044630-AE Trifluoroacetic acid, HPLC Grade, 99.5+% 100mL ₹7422 2022-05-26 Buy
ALFA India ALF-A12198-36 Trifluoroacetic acid, 99% 500g ₹11517 2022-05-26 Buy
ALFA India ALF-031771-36 Trifluoroacetic acid, 99.5+% 500g ₹13935 2022-05-26 Buy
ALFA India ALF-044630-5Y Trifluoroacetic acid, HPLC Grade, 99.5+% 4x100mL ₹27541 2022-05-26 Buy
ALFA India ALF-031771-A4 Trifluoroacetic acid, 99.5+% 2.5kg ₹31248 2022-05-26 Buy
ALFA India ALF-A12198-0E Trifluoroacetic acid, 99% 2500g ₹31706 2022-05-26 Buy
ALFA India ALF-044630-AP Trifluoroacetic acid, HPLC Grade, 99.5+% 500mL ₹32688 2022-05-26 Buy
ALFA India ALF-044630-AY Trifluoroacetic acid, HPLC Grade, 99.5+% 4x500mL ₹101802 2022-05-26 Buy
TCI Chemicals (India) A5711 Trifluoroacetic Acid (ca. 0.5mol/L in Water) [Ion-Pair Reagent for LC-MS] 10ML ₹2000 2022-05-26 Buy
TCI Chemicals (India) T0431 Trifluoroacetic Acid 25G ₹2000 2022-05-26 Buy
TCI Chemicals (India) T0431 Trifluoroacetic Acid 100G ₹3600 2022-05-26 Buy
TCI Chemicals (India) Q0053 Trifluoroacetic Acid [Sequenation Reagent] 25ML ₹6500 2022-05-26 Buy
TCI Chemicals (India) T0431 Trifluoroacetic Acid 500G ₹9600 2022-05-26 Buy
Sigma-Aldrich(India) T6508 Trifluoroacetic acid ReagentPlus?, 99% 1AMP ₹2143.35 2022-06-14 Buy

Properties

Melting point :-15.4 °C (lit.)
Boiling point :72.4 °C (lit.)
Density :1.489 g/mL at 20 °C (lit.)
vapor density :3.9 (vs air)
vapor pressure :97.5 mm Hg ( 20 °C)
refractive index :n20/D 1.3(lit.)
Flash point :None
storage temp. :Store at +15°C to +25°C.
solubility :Miscible with ether, acetone, ethanol, benzene, hexane, and CCl<sub>4</sub>
pka :-0.3(at 25℃)
form :Liquid
Specific Gravity :1.480
color :Colorless
PH :1 (10g/l, H2O)
Odor :Sharp, pungent odor
PH Range :1
Water Solubility :miscible
Sensitive :Hygroscopic
λmax :λ: 260 nm Amax: 0.9
λ: 270 nm Amax: 0.10
λ: 280 nm Amax: 0.05
λ: 290 nm Amax: 0.04
λ: 300 nm Amax: 0.03
λ: 320 nm Amax: 0.025 Merck :14,9681
BRN :742035
Dielectric constant :23.7(20℃)
Stability :Stable. Incompatible with combustible material, strong bases, water, strong oxidizing agents. Non-combustible. Hygroscopic. May react violently with bases.
InChIKey :DTQVDTLACAAQTR-UHFFFAOYSA-N
CAS DataBase Reference :76-05-1(CAS DataBase Reference)
NIST Chemistry Reference :Acetic acid, trifluoro-(76-05-1)
EPA Substance Registry System :Acetic acid, 2,2,2-trifluoro- (76-05-1)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Trifluoroacetic acid (TFA, molecular formula: CF3COOH) is a kind of colorless, volatile and fuming liquid with a similar odor as acetic acid. It is hygroscopic and has irritating odor. It has strong acidic property due to being affected by the electron-attracting trifluoromethyl group with its acidicity being 100000 higher than acetic acid. It has a melting point being-15.2 ℃, boiling point being 72.4 ℃, and the density being 1.5351g/cm3 (1℃). It is miscible with water, fluorinated hydrocarbons, methanol, ethanol, ethyl ether, acetone, benzene, carbon tetrachloride, and hexane; it is partially soluble in carbon disulfide and alkane containing more than six carbons. It is an excellent solvent of protein and polyester. It is also a good solvent for the organic reaction which allows obtaining certain results which are difficult in the cases of application of common solvents. For example, when quinolone is being catalyzed for hydrogenation in a common solvent, the pyridine ring is preferentially hydrogenated; in contrast, the benzene ring will be preferentially hydrogenated in the presence of trifluoroacetic acid as the solvent. Trifluoroacetic acid is decomposed into carbon dioxide and fluorine in the presence of aniline. It can be reduced by sodium borohydride or lithium aluminum hydride into trifluoroacetic acetaldehyde and trifluoro-ethanol. It is stable at temperature higher than 205 ℃ stable. But its ester and amides derivatives are easily subject to hydrolysis which allows them to prepare carbohydrate, amino acids, and peptide derivative in the form of acid or anhydride. It is easily to be dehydrated under action of phosphorus pentoxide and be converted to trifluoroacetic anhydride.
Trifluoroacetic acid is a kind of important intermediates of fat fluorine. Owing to the special structure of trifluoromethyl, it has a different property from other alcohols and can participate in a variety of organic reactions, especially being used in the field of the synthesis of fluorine-containing pharmaceutical, pesticides and dyes. Its domestic and foreign demand is increasing and has become one of the important intermediates for fluorine-containing fine chemicals.

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