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ChemicalBook >> CAS DataBase List >> [4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone

[4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone

[4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone price.
  • $33 - $6325
  • Product name: [4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone
  • CAS: 1351758-81-0
  • MF: C17H20ClN5O3
  • MW: 377.83
  • EINECS:
  • MDL Number:MFCD28160565
  • Synonyms:[4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone;HG-10-102-01;(4-((5-chloro-4- (methylamino)pyrimidin-2-yl)amino)- 3- methoxyphenyl)(morpholino)methano ne;Methanone, [4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinyl-;CS-949;LRRK2 INHIBITOR 1;Parkinson’s disease,Leucine-rich repeat kinase 2,inhibit,Ser910,BBB,HG 10 102 01,Radiosynthesis,Mouse embryonic fibroblast cells,Mouse Swiss 3T3 cells,MAP kinase interacting kinase,Ser935,MNK,Mitogen activated protein kinase interacting kinase,HG1010201,PET,Inhibitor,MAPK interacting kinase,HEK293 cells,LRRK2,Positron emission tomography
Price18 Properties Safety Information Description
18 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product number1064DP
  • Product descriptionCID58539301
  • Packaging1mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1262
  • Product descriptionHG-10-102-01
  • Packaging10mM(in 1mL DMSO)
  • Price$123
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1262
  • Product descriptionHG-10-102-01
  • Packaging5mg
  • Price$124
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1262
  • Product descriptionHG-10-102-01
  • Packaging10mg
  • Price$219
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1262
  • Product descriptionHG-10-102-01
  • Packaging25mg
  • Price$390
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1262
  • Product descriptionHG-10-102-01
  • Packaging50mg
  • Price$665
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number20049
  • Product descriptionHG-10-102-01 ≥98%
  • Packaging1mg
  • Price$33
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20049
  • Product descriptionHG-10-102-01 ≥98%
  • Packaging5mg
  • Price$120
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20049
  • Product descriptionHG-10-102-01 ≥98%
  • Packaging10mg
  • Price$190
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number20049
  • Product descriptionHG-10-102-01 ≥98%
  • Packaging25mg
  • Price$435
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM110500
  • Product descriptionHG-10-102-01 98%
  • Packaging10mg
  • Price$248
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM110500
  • Product descriptionHG-10-102-01 98%
  • Packaging50mg
  • Price$912
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003779
  • Product descriptionHG-10-102-01 98+%
  • Packaging5mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003779
  • Product descriptionHG-10-102-01 98+%
  • Packaging10mg
  • Price$265
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003779
  • Product descriptionHG-10-102-01 98+%
  • Packaging50mg
  • Price$975
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9496
  • Product descriptionHG-10-102-01 >98%
  • Packaging250mg
  • Price$1300
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1064DP CID58539301 1mg $135 2021-12-16 Buy
ApexBio Technology B1262 HG-10-102-01 10mM(in 1mL DMSO) $123 2021-12-16 Buy
ApexBio Technology B1262 HG-10-102-01 5mg $124 2021-12-16 Buy
ApexBio Technology B1262 HG-10-102-01 10mg $219 2021-12-16 Buy
ApexBio Technology B1262 HG-10-102-01 25mg $390 2021-12-16 Buy
ApexBio Technology B1262 HG-10-102-01 50mg $665 2021-12-16 Buy
Cayman Chemical 20049 HG-10-102-01 ≥98% 1mg $33 2024-03-01 Buy
Cayman Chemical 20049 HG-10-102-01 ≥98% 5mg $120 2024-03-01 Buy
Cayman Chemical 20049 HG-10-102-01 ≥98% 10mg $190 2024-03-01 Buy
Cayman Chemical 20049 HG-10-102-01 ≥98% 25mg $435 2024-03-01 Buy
Chemenu CM110500 HG-10-102-01 98% 10mg $248 2021-12-16 Buy
Chemenu CM110500 HG-10-102-01 98% 50mg $912 2021-12-16 Buy
Crysdot CD31003779 HG-10-102-01 98+% 5mg $190 2021-12-16 Buy
Crysdot CD31003779 HG-10-102-01 98+% 10mg $265 2021-12-16 Buy
Crysdot CD31003779 HG-10-102-01 98+% 50mg $975 2021-12-16 Buy
DC Chemicals DC9496 HG-10-102-01 >98% 250mg $1300 2021-12-16 Buy
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Properties

Boiling point :641.1±65.0 °C(Predicted)
Density :1.381±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥18.9 mg/mL in DMSO; ≥7.64 mg/mL in EtOH with ultrasonic
form :solid
pka :4.60±0.10(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM). It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively). HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.

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career henan chemical co
[4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone
$1.00 /1KG
[4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone CAS:1351758-81-0
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