3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
![3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione price.](/CAS2/GIF/425637-18-9.gif)
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- $49 - $2839
- Product name: 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
- CAS: 425637-18-9
- MF: C25H22N6O2
- MW: 438.48
- EINECS:
- MDL Number:MFCD16038049
- Synonyms:3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione;Sotrastaurin;Sotrastaurin (AEB071);3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione;Dusquetide;Sotrastaurin - AEB 071 | NVP-AEB 071;CS-1479;AEB071; AEB 071; AEB-071
33 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1MG
- 2mg
- 5MG
- 10MG
- 25mg
- 50mg
- 2x25mg
- 100mg
- 1000mg
- 10mM(in 1mL DMSO)
- 250mg
- ManufacturerAK Scientific
- Product numberY6229
- Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione
- Packaging250mg
- Price$327
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014152
- Product descriptionSOTRASTAURIN 95.00%
- Packaging1MG
- Price$430
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014152
- Product descriptionSOTRASTAURIN 95.00%
- Packaging5MG
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014152
- Product descriptionSOTRASTAURIN 95.00%
- Packaging10MG
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8525
- Product descriptionSotrastaurin(AEB071)
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8525
- Product descriptionSotrastaurin(AEB071)
- Packaging10mM(in 1mL DMSO)
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8525
- Product descriptionSotrastaurin(AEB071)
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8525
- Product descriptionSotrastaurin(AEB071)
- Packaging25mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8525
- Product descriptionSotrastaurin(AEB071)
- Packaging50mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60161
- Product descriptionSotrastaurin ≥98%
- Packaging10mg
- Price$418
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1635
- Product descriptionSotrastaurin-AEB071|NVP-AEB071 99%
- Packaging2mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1635
- Product descriptionSotrastaurin-AEB071|NVP-AEB071 99%
- Packaging5mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1635
- Product descriptionSotrastaurin-AEB071|NVP-AEB071 99%
- Packaging2x25mg
- Price$396
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181327
- Product descriptionSotrastaurin >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181327
- Product descriptionSotrastaurin >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181327
- Product descriptionSotrastaurin >98%
- Packaging1000mg
- Price$2839
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y6229 | 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione | 250mg | $327 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014152 | SOTRASTAURIN 95.00% | 1MG | $430 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014152 | SOTRASTAURIN 95.00% | 5MG | $550 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014152 | SOTRASTAURIN 95.00% | 10MG | $700 | 2021-12-16 | Buy |
| ApexBio Technology | A8525 | Sotrastaurin(AEB071) | 5mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A8525 | Sotrastaurin(AEB071) | 10mM(in 1mL DMSO) | $135 | 2021-12-16 | Buy |
| ApexBio Technology | A8525 | Sotrastaurin(AEB071) | 10mg | $180 | 2021-12-16 | Buy |
| ApexBio Technology | A8525 | Sotrastaurin(AEB071) | 25mg | $470 | 2021-12-16 | Buy |
| ApexBio Technology | A8525 | Sotrastaurin(AEB071) | 50mg | $850 | 2021-12-16 | Buy |
| Arctom | CFN60161 | Sotrastaurin ≥98% | 10mg | $418 | 2021-12-16 | Buy |
| Axon Medchem | Axon1635 | Sotrastaurin-AEB071|NVP-AEB071 99% | 2mg | $55 | 2021-12-16 | Buy |
| Axon Medchem | Axon1635 | Sotrastaurin-AEB071|NVP-AEB071 99% | 5mg | $88 | 2021-12-16 | Buy |
| Axon Medchem | Axon1635 | Sotrastaurin-AEB071|NVP-AEB071 99% | 2x25mg | $396 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181327 | Sotrastaurin >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181327 | Sotrastaurin >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181327 | Sotrastaurin >98% | 1000mg | $2839 | 2021-12-16 | Buy |
Properties
Density :1.406
storage temp. :Store at -20°C
solubility :≥21.9 mg/mL in DMSO; insoluble in H2O; ≥2.55 mg/mL in EtOH with ultrasonic
form :solid
pka :7.39±0.60(Predicted)
storage temp. :Store at -20°C
solubility :≥21.9 mg/mL in DMSO; insoluble in H2O; ≥2.55 mg/mL in EtOH with ultrasonic
form :solid
pka :7.39±0.60(Predicted)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Sotrastaurin is a protein kinase C (PKC) inhibitor that displays immunosuppressive activity, blocking T cell activation through the disruption of downstream NF-κB signaling. In cell-free assays, sotrastaurin was reported to inhibit PKCα, βI, δ, ε, η, and θ with Ki values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM, respectively. Sotrastaurin can prevent the production of various cytokines by activated T cells, macrophages, and keratinocytes in vitro and has been shown to inhibit an acute allergic contact dermatitis response in rats when dosed orally at 30 mg. However, clinical investigation of sotrastaurin for its potential to prevent renal transplant rejection was halted during phase II testing due to high incidence of rejection. Sotrastaurin is also reported to activate Wnt/β-catenin signaling via the inhibition of glycogen synthase kinase 3 (IC50s = 229 and 172 nM for α and β isoforms, respectively), which is essential for embryogenesis and adult stem cell maintenance.More related product prices
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