A77 1726
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- $9 - $1732.5
- Product name: A77 1726
- CAS: 163451-81-8
- MF: C12H9F3N2O2
- MW: 270.21
- EINECS:642-273-4
- MDL Number:MFCD00910058
- Synonyms:A 1726;HMR 1726;(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide;LeflunoMide EP IMpurity B;Leflunomide Impurity 2(Leflunomide EP Impurity B);A-771726;A 771726;A771726;A-771726;A 77-1726;A771726;HMR-1726;(2Z)-2-Cyano-3-hydroxy-N-[4-(triflu
39 prices
Selected condition：
Brand
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Biosynth Carbosynth
- Cayman Chemical
- Chem-Impex
- Crysdot
- CSNpharm
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1mL
- 1g
- 2.5g
- 5g
- 10g
- 25g
- ManufacturerAmbeed
- Product numberA122692
- Product description(Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+%
- Packaging10mg
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA122692
- Product description(Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+%
- Packaging50mg
- Price$16
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA122692
- Product description(Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+%
- Packaging100mg
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA122692
- Product description(Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+%
- Packaging250mg
- Price$52
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA122692
- Product description(Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+%
- Packaging1g
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA122692
- Product description(Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+%
- Packaging5g
- Price$411
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0000341
- Product descriptionTERIFLUNOMIDE 95.00%
- Packaging10MG
- Price$721.88
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0000341
- Product descriptionTERIFLUNOMIDE 95.00%
- Packaging100MG
- Price$1732.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC5603
- Product descriptionA-771726
- Packaging5mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC5603
- Product descriptionA-771726
- Packaging10mg
- Price$129
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC5603
- Product descriptionA-771726
- Packaging25mg
- Price$272
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2837
- Product descriptionTeriflunomide
- Packaging10mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2837
- Product descriptionTeriflunomide
- Packaging50mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2837
- Product descriptionTeriflunomide
- Packaging250mg
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2837
- Product descriptionTeriflunomide
- Packaging1g
- Price$249
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT16895
- Product descriptionTeriflunomide
- Packaging50mg
- Price$40
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A122692 | (Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+% | 10mg | $9 | 2021-12-16 | Buy |
| Ambeed | A122692 | (Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+% | 50mg | $16 | 2021-12-16 | Buy |
| Ambeed | A122692 | (Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+% | 100mg | $28 | 2021-12-16 | Buy |
| Ambeed | A122692 | (Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+% | 250mg | $52 | 2021-12-16 | Buy |
| Ambeed | A122692 | (Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+% | 1g | $120 | 2021-12-16 | Buy |
| Ambeed | A122692 | (Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide 98+% | 5g | $411 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0000341 | TERIFLUNOMIDE 95.00% | 10MG | $721.88 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0000341 | TERIFLUNOMIDE 95.00% | 100MG | $1732.5 | 2021-12-16 | Buy |
| ApexBio Technology | C5603 | A-771726 | 5mg | $68 | 2021-12-16 | Buy |
| ApexBio Technology | C5603 | A-771726 | 10mg | $129 | 2021-12-16 | Buy |
| ApexBio Technology | C5603 | A-771726 | 25mg | $272 | 2021-12-16 | Buy |
| AvaChem | 2837 | Teriflunomide | 10mg | $49 | 2021-12-16 | Buy |
| AvaChem | 2837 | Teriflunomide | 50mg | $79 | 2021-12-16 | Buy |
| AvaChem | 2837 | Teriflunomide | 250mg | $149 | 2021-12-16 | Buy |
| AvaChem | 2837 | Teriflunomide | 1g | $249 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT16895 | Teriflunomide | 50mg | $40 | 2021-12-16 | Buy |
Properties
Melting point :229-232°C
Boiling point :410.8±45.0 °C(Predicted)
Density :1.424±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :5.20±0.50(Predicted)
form :powder
color :white to beige
λmax :203nm(MeOH)(lit.)
Merck :14,9165
Stability :Hygroscopic
InChIKey :UTNUDOFZCWSZMS-YFHOEESVSA-N
Boiling point :410.8±45.0 °C(Predicted)
Density :1.424±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :5.20±0.50(Predicted)
form :powder
color :white to beige
λmax :203nm(MeOH)(lit.)
Merck :14,9165
Stability :Hygroscopic
InChIKey :UTNUDOFZCWSZMS-YFHOEESVSA-N
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.More related product prices
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