AAL-993
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- $51 - $3000
- Product name: AAL-993
- CAS: 269390-77-4
- MF: C20H16F3N3O
- MW: 371.36
- EINECS:
- MDL Number:MFCD18251410
- Synonyms:AAL-993;CS-2315;2-[(4-Pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]benzami de;VEGFR Tyrosine Kinase Inhibitor VI, AAL-993 - CAS 269390-77-4 - Calbiochem;2-(Pyridin-4-ylmethylamino)-N-[3-(trifluoromethyl)phenyl]benzamide;Benzamide, 2-[(4-pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]-;antiangiogenic,antitumor properties,AAL 993,VEGFR1,VEGFR2,orally active,VEGFR,AAL993,VEGFR3,Inhibitor,VEGFR inhibitor,AAL-993,Vascular endothelial growth factor receptor,inhibit;AAL 993, VEGFR inhibitor
36 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- Manufactureraablocks
- Product numberAA007MB5
- Product descriptionAAL-993
- Packaging1mg
- Price$51
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MB5
- Product descriptionAAL-993
- Packaging5mg
- Price$92
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MB5
- Product descriptionAAL-993
- Packaging10mg
- Price$139
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MB5
- Product descriptionAAL-993
- Packaging25mg
- Price$252
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MB5
- Product descriptionAAL-993
- Packaging50mg
- Price$384
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MB5
- Product descriptionAAL-993
- Packaging100mg
- Price$558
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MB5
- Product descriptionAAL-993
- Packaging500mg
- Price$1164
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238452
- Product descriptionAAL-993 98%
- Packaging100MG
- Price$505
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238452
- Product descriptionAAL-993 98%
- Packaging25MG
- Price$175
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number7633CP
- Product description2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide
- Packaging1mg
- Price$179
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000513
- Product descriptionAAL-993 95.00%
- Packaging1MG
- Price$177.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000513
- Product descriptionAAL-993 95.00%
- Packaging5MG
- Price$502.63
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3730
- Product descriptionAAL-993
- Packaging5mg
- Price$129
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC3730
- Product descriptionAAL-993
- Packaging1mg
- Price$61
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-19986
- Product descriptionAAL993 99.14%
- Packaging5mg
- Price$105
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-19986
- Product descriptionAAL993 99.14%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$110
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA007MB5 | AAL-993 | 1mg | $51 | 2026-05-28 | Buy |
| aablocks | AA007MB5 | AAL-993 | 5mg | $92 | 2026-05-28 | Buy |
| aablocks | AA007MB5 | AAL-993 | 10mg | $139 | 2026-05-28 | Buy |
| aablocks | AA007MB5 | AAL-993 | 25mg | $252 | 2026-05-28 | Buy |
| aablocks | AA007MB5 | AAL-993 | 50mg | $384 | 2026-05-28 | Buy |
| aablocks | AA007MB5 | AAL-993 | 100mg | $558 | 2026-05-28 | Buy |
| aablocks | AA007MB5 | AAL-993 | 500mg | $1164 | 2026-05-28 | Buy |
| ACHEMBLOCK | Z238452 | AAL-993 98% | 100MG | $505 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238452 | AAL-993 98% | 25MG | $175 | 2026-05-27 | Buy |
| AK Scientific | 7633CP | 2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide | 1mg | $179 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000513 | AAL-993 95.00% | 1MG | $177.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000513 | AAL-993 95.00% | 5MG | $502.63 | 2021-12-16 | Buy |
| ApexBio Technology | C3730 | AAL-993 | 5mg | $129 | 2026-05-06 | Buy |
| ApexBio Technology | C3730 | AAL-993 | 1mg | $61 | 2026-05-06 | Buy |
| Arctom | HY-19986 | AAL993 99.14% | 5mg | $105 | 2026-05-26 | Buy |
| Arctom | HY-19986 | AAL993 99.14% | 10mM*1mLinDMSO(Solid+Solvent) | $110 | 2026-05-26 | Buy |
Properties
Melting point :158-160 °C
Boiling point :441.3±45.0 °C(Predicted)
Density :1.349±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
form :Off-white powder
pka :12.95±0.70(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
InChIKey :BLAFVGLBBOPRLP-UHFFFAOYSA-N
SMILES :FC(F)(F)c1cc(ccc1)NC(=O)c2c(cccc2)NCc3ccncc3
Boiling point :441.3±45.0 °C(Predicted)
Density :1.349±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
form :Off-white powder
pka :12.95±0.70(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
InChIKey :BLAFVGLBBOPRLP-UHFFFAOYSA-N
SMILES :FC(F)(F)c1cc(ccc1)NC(=O)c2c(cccc2)NCc3ccncc3
Safety Information
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Description
AAL-993 is a potent inhibitor of VEGF receptors, inhibiting VEGFR1, 2, and 3 with IC50 values of 130, 23, and 18 nM, respectively. It less potently inhibits c-Kit, colony stimulating factor 1 receptor, PGDF receptor β, and EGF receptor (IC50s = 236, 380, 640, and 1,040 nM, respectively) and is without effect on a number of other tyrosine kinases. AAL-993 is orally bioavailable in vivo, blocks VEGF-induced angiogenesis, and prevents the growth of primary tumors and spontaneous peripheral metastases in mice. It also inhibits hypoxia-mediated increase in hypoxia-inducible factor-1 transcriptional activity in an ERK-dependent manner (IC50 = ~5 μM).More related product prices
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