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ChemicalBook >> CAS DataBase List >> CAY10603

CAY10603

CAY10603 price.
  • $23 - $2970
  • Product name: CAY10603
  • CAS: 1045792-66-2
  • MF: C22H30N4O6
  • MW: 446.5
  • EINECS:
  • MDL Number:MFCD17010286
  • Synonyms:N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester;HDAC6 inhibitor ISOX;CAY10603;Isox;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate;HDAC6 Inhibitor;Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem;CAY10603; CAY-10603; CAY 10603.
54 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • ApexBio Technology
  • Axon Medchem
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 10mM(in1mLDMSO)
  • 1000μg
  • 1mg
  • 250mg
  • 10mM*1mLinDMSO
  • 1 mg
  • 1 unit
  • 10mM(in 1mL DMSO)
  • 500μg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1G
  • Manufactureraablocks
  • Product numberAA007XO8
  • Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
  • Packaging1mg
  • Price$23
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA007XO8
  • Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
  • Packaging5mg
  • Price$47
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA007XO8
  • Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
  • Packaging10mg
  • Price$76
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA007XO8
  • Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
  • Packaging25mg
  • Price$141
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA007XO8
  • Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
  • Packaging50mg
  • Price$239
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA007XO8
  • Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
  • Packaging100mg
  • Price$407
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT101397
  • Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
  • Packaging100MG
  • Price$495
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT101397
  • Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
  • Packaging100MG
  • Price$495
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT101397
  • Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
  • Packaging25MG
  • Price$170
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT101397
  • Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
  • Packaging25MG
  • Price$170
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT101397
  • Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
  • Packaging1G
  • Price$2970
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT101397
  • Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
  • Packaging1G
  • Price$2970
  • Updated2026-05-27
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4856
  • Product descriptionCAY10603
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4856
  • Product descriptionCAY10603
  • Packaging5mg
  • Price$116
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4856
  • Product descriptionCAY10603
  • Packaging10mM(in 1mL DMSO)
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4856
  • Product descriptionCAY10603
  • Packaging10mM(in1mLDMSO)
  • Price$121
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA007XO8 Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98% 1mg $23 2026-05-28 Buy
aablocks AA007XO8 Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98% 5mg $47 2026-05-28 Buy
aablocks AA007XO8 Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98% 10mg $76 2026-05-28 Buy
aablocks AA007XO8 Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98% 25mg $141 2026-05-28 Buy
aablocks AA007XO8 Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98% 50mg $239 2026-05-28 Buy
aablocks AA007XO8 Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98% 100mg $407 2026-05-28 Buy
ACHEMBLOCK T101397 tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98% 100MG $495 2026-05-25 Buy
ACHEMBLOCK T101397 tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98% 100MG $495 2026-05-27 Buy
ACHEMBLOCK T101397 tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98% 25MG $170 2026-05-25 Buy
ACHEMBLOCK T101397 tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98% 25MG $170 2026-05-27 Buy
ACHEMBLOCK T101397 tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98% 1G $2970 2026-05-25 Buy
ACHEMBLOCK T101397 tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98% 1G $2970 2026-05-27 Buy
ApexBio Technology B4856 CAY10603 5mg $105 2021-12-16 Buy
ApexBio Technology B4856 CAY10603 5mg $116 2026-05-06 Buy
ApexBio Technology B4856 CAY10603 10mM(in 1mL DMSO) $120 2021-12-16 Buy
ApexBio Technology B4856 CAY10603 10mM(in1mLDMSO) $121 2026-05-06 Buy

Properties

Density :1.231±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
form :Beige to light brown solid
pka :9.47±0.20(Predicted)
color :White to light yellow
InChIKey :WWGBHDIHIVGYLZ-UHFFFAOYSA-N
SMILES :N(O)C(=O)CCCCCCNC(=O)c1n[o]c(c1)c2ccc(cc2)NC(=O)OC(C)(C)C

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

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