Doramapimod
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- $7 - $2200
- Product name: Doramapimod
- CAS: 285983-48-4
- MF: C31H37N5O3
- MW: 527.66
- EINECS:1308068-626-2
- MDL Number:MFCD09752957
- Synonyms:1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea;1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea;1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea;DoraMapiMod, BIBR-796;BIBR-796(DoraMapiMod);BIRB 796BS;N-[3-(1,1-DiMethylethyl)-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-Morpholinyl)ethoxy]-1-naphthalenyl]urea;DoraMapin BIBR796
55 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1MG
- 1unit
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 10
- 500mg
- 1g
- 50
- 5g
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberX7401
- Product descriptionDoramapimod
- Packaging25mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103377
- Product descriptionDoramapimod 99%
- Packaging5mg
- Price$7
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103377
- Product descriptionDoramapimod 99%
- Packaging10mg
- Price$10
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103377
- Product descriptionDoramapimod 99%
- Packaging50mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103377
- Product descriptionDoramapimod 99%
- Packaging100mg
- Price$37
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103377
- Product descriptionDoramapimod 99%
- Packaging250mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103377
- Product descriptionDoramapimod 99%
- Packaging1g
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103377
- Product descriptionDoramapimod 99%
- Packaging5g
- Price$537
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000097
- Product descriptionDORAMAPIMOD 95.00%
- Packaging1MG
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000097
- Product descriptionDORAMAPIMOD 95.00%
- Packaging10MG
- Price$750.75
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000097
- Product descriptionDORAMAPIMOD 95.00%
- Packaging100MG
- Price$1963.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5639
- Product descriptionBIRB796(Doramapimod)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5639
- Product descriptionBIRB796(Doramapimod)
- Packaging10mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5639
- Product descriptionBIRB796(Doramapimod)
- Packaging10mM(in 1mL DMSO)
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5639
- Product descriptionBIRB796(Doramapimod)
- Packaging50mg
- Price$137
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5639
- Product descriptionBIRB796(Doramapimod)
- Packaging100mg
- Price$185
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7401 | Doramapimod | 25mg | $98 | 2021-12-16 | Buy |
| Ambeed | A103377 | Doramapimod 99% | 5mg | $7 | 2021-12-16 | Buy |
| Ambeed | A103377 | Doramapimod 99% | 10mg | $10 | 2021-12-16 | Buy |
| Ambeed | A103377 | Doramapimod 99% | 50mg | $25 | 2021-12-16 | Buy |
| Ambeed | A103377 | Doramapimod 99% | 100mg | $37 | 2021-12-16 | Buy |
| Ambeed | A103377 | Doramapimod 99% | 250mg | $66 | 2021-12-16 | Buy |
| Ambeed | A103377 | Doramapimod 99% | 1g | $156 | 2021-12-16 | Buy |
| Ambeed | A103377 | Doramapimod 99% | 5g | $537 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000097 | DORAMAPIMOD 95.00% | 1MG | $126 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000097 | DORAMAPIMOD 95.00% | 10MG | $750.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000097 | DORAMAPIMOD 95.00% | 100MG | $1963.5 | 2021-12-16 | Buy |
| ApexBio Technology | A5639 | BIRB796(Doramapimod) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A5639 | BIRB796(Doramapimod) | 10mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A5639 | BIRB796(Doramapimod) | 10mM(in 1mL DMSO) | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A5639 | BIRB796(Doramapimod) | 50mg | $137 | 2021-12-16 | Buy |
| ApexBio Technology | A5639 | BIRB796(Doramapimod) | 100mg | $185 | 2021-12-16 | Buy |
Properties
Melting point :142-143 °C
Boiling point :631.6±55.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
form :solid
pka :13.47±0.70(Predicted)
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Boiling point :631.6±55.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
form :solid
pka :13.47±0.70(Predicted)
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM. At 10 μM, doramapimod inhibits JNK2α2 in vitro, but at the low concentration necessary to inhibit p38 MAPK, it does not affect the phosphorylation of JNK substrates in cells.Related product price
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