GNF5
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- $10 - $2245.7
- Product name: GNF5
- CAS: 778277-15-9
- MF: C20H17F3N4O3
- MW: 418.37
- EINECS:200-256-5
- MDL Number:MFCD16877246
- Synonyms:GNF 5;GNF5;GNF-5;N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide;ert-butyl 2-oxopiperidine-1-carboxylate;GNF 5 N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide;N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-5;GNF-5, >=98%
56 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10mM(1mLinDMSO)
- 1mg
- 10mM*1mLinDMSO
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 10
- 200mg
- 50
- 10mM*1mLinDMSO(Solution)
- 250mg
- 1G
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- 1000mg
- Manufactureraablocks
- Product numberAA00G3LN
- Product descriptionN-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide 99%
- Packaging10mg
- Price$17
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3LN
- Product descriptionN-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide ≥97%
- Packaging5mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3LN
- Product descriptionN-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide ≥97%
- Packaging25mg
- Price$37
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3LN
- Product descriptionN-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide ≥97%
- Packaging50mg
- Price$66
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3LN
- Product descriptionN-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
- Packaging100mg
- Price$116
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3LN
- Product descriptionN-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
- Packaging200mg
- Price$192
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33864
- Product descriptionGNF-5 98%
- Packaging100MG
- Price$90
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33864
- Product descriptionGNF-5 98%
- Packaging25MG
- Price$32
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33864
- Product descriptionGNF-5 98%
- Packaging1G
- Price$675
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2436AH
- Product descriptionN-(2-Hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide
- Packaging1g
- Price$1072
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2436AH
- Product descriptionN-(2-Hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide
- Packaging5mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA117001
- Product descriptionGNF-5 99%
- Packaging100mg
- Price$117
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA117001
- Product descriptionGNF-5 99%
- Packaging1mg
- Price$13
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA117001
- Product descriptionGNF-5 99%
- Packaging10mg
- Price$21
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA117001
- Product descriptionGNF-5 99%
- Packaging50mg
- Price$68
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA117001
- Product descriptionGNF-5 99%
- Packaging250mg
- Price$234
- Updated2026-06-05
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00G3LN | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide 99% | 10mg | $17 | 2026-05-28 | Buy |
| aablocks | AA00G3LN | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide ≥97% | 5mg | $10 | 2026-05-28 | Buy |
| aablocks | AA00G3LN | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide ≥97% | 25mg | $37 | 2026-05-28 | Buy |
| aablocks | AA00G3LN | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide ≥97% | 50mg | $66 | 2026-05-28 | Buy |
| aablocks | AA00G3LN | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide | 100mg | $116 | 2026-05-28 | Buy |
| aablocks | AA00G3LN | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide | 200mg | $192 | 2026-05-28 | Buy |
| ACHEMBLOCK | O33864 | GNF-5 98% | 100MG | $90 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33864 | GNF-5 98% | 25MG | $32 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33864 | GNF-5 98% | 1G | $675 | 2026-05-27 | Buy |
| AK Scientific | 2436AH | N-(2-Hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide | 1g | $1072 | 2021-12-16 | Buy |
| AK Scientific | 2436AH | N-(2-Hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide | 5mg | $82 | 2021-12-16 | Buy |
| Ambeed | A117001 | GNF-5 99% | 100mg | $117 | 2026-06-05 | Buy |
| Ambeed | A117001 | GNF-5 99% | 1mg | $13 | 2026-06-05 | Buy |
| Ambeed | A117001 | GNF-5 99% | 10mg | $21 | 2026-06-05 | Buy |
| Ambeed | A117001 | GNF-5 99% | 50mg | $68 | 2026-06-05 | Buy |
| Ambeed | A117001 | GNF-5 99% | 250mg | $234 | 2026-06-05 | Buy |
Properties
Boiling point :612.4±55.0 °C(Predicted)
Density :1.385±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: soluble10mg/mL (clear solution)
pka :13.36±0.46(Predicted)
form :powder
color :white to beige
InChI :1S/C20H17F3N4O3/c21-20(22,23)30-16-6-4-15(5-7-16)27-18-11-17(25-12-26-18)13-2-1-3-14(10-13)19(29)24-8-9-28/h1-7,10-12,28H,8-9H2,(H,24,29)(H,25,26,27)
InChIKey :IIQUYGWWHIHOCF-UHFFFAOYSA-N
SMILES :OCCNC(=O)c1cccc(c1)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2
Density :1.385±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: soluble10mg/mL (clear solution)
pka :13.36±0.46(Predicted)
form :powder
color :white to beige
InChI :1S/C20H17F3N4O3/c21-20(22,23)30-16-6-4-15(5-7-16)27-18-11-17(25-12-26-18)13-2-1-3-14(10-13)19(29)24-8-9-28/h1-7,10-12,28H,8-9H2,(H,24,29)(H,25,26,27)
InChIKey :IIQUYGWWHIHOCF-UHFFFAOYSA-N
SMILES :OCCNC(=O)c1cccc(c1)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia. GNF-5 is the N-hydroxyethyl carboamide analog of GNF-2 , a selective allosteric inhibitor of Bcr-Abl. GNF-5 demonstrates IC50 values of 4.52, 0.38, and 0.93 μM against Bcr-Abl mutants G250E, E255V, and M351T, respectively. When used in combination with the ATP-competitive Bcr-Abl inhibitors imatinib or nilotinib , GNF-5 displays additive inhibitory activity against T315I Bcr-Abl mutants both in in vitro assays and in a recalcitrant T315I Bcr-Abl mutant mouse bone marrow transplantation model.Related product price
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