ITF2357
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- $30 - $1950
- Product name: ITF2357
- CAS: 732302-99-7
- MF: C24H30ClN3O5
- MW: 475.9651
- EINECS:200-258-5
- MDL Number:MFCD18385007
- Synonyms:(6-((diethylamino)methyl)naphthalen-2-yl)methyl 4-(hydroxycarbamoyl)phenylcarbamate hydrochloride hydrate;ITF2357;ITF2357 (Givinostat);N-[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester hydrochloride hydrate;Givinostat (hydrochloride monohydrate);Givinostat Hydrochloride Hydrate;Givinostat (ITF2357) HCl monohydrate;Givinostat(HCl hydrate)
52 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TRC
Package
- 10mM(in1mLDMSO)
- EvaluationSample
- 5mg
- 1MG
- 5.00mg
- 10mM*1mLinDMSO
- 10mg
- 25mg
- 50mg
- 50.00mg
- 100mg
- 100.00mg
- 200mg
- 250mg
- 1G
- Manufactureraablocks
- Product numberAA00FF6F
- Product description(6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98%
- Packaging5mg
- Price$52
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FF6F
- Product description(6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98
- Packaging10mg
- Price$82
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FF6F
- Product description(6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98
- Packaging25mg
- Price$142
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FF6F
- Product description(6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98%
- Packaging50mg
- Price$189
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FF6F
- Product description(6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98%
- Packaging100mg
- Price$278
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FF6F
- Product description(6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98%
- Packaging250mg
- Price$389
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX209266
- Product descriptionGivinostat hydrochloride hydrate 97%
- Packaging100MG
- Price$290
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX209266
- Product descriptionGivinostat hydrochloride hydrate 97%
- Packaging1G
- Price$845
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7528
- Product descriptionGivinostat
- Packaging50mg
- Price$834
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007793
- Product descriptionITF2357 95.00%
- Packaging5MG
- Price$495.94
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007793
- Product descriptionITF2357 95.00%
- Packaging1MG
- Price$153.3
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4093
- Product descriptionITF2357 (Givinostat)
- Packaging10mg
- Price$190
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4093
- Product descriptionITF2357 (Givinostat)
- PackagingEvaluationSample
- Price$30
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4093
- Product descriptionITF2357 (Givinostat)
- Packaging5mg
- Price$110
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4093
- Product descriptionITF2357 (Givinostat)
- Packaging10mM(in1mLDMSO)
- Price$120
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4093
- Product descriptionITF2357(Givinostat)
- Packaging50mg
- Price$670
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00FF6F | (6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98% | 5mg | $52 | 2026-05-28 | Buy |
| aablocks | AA00FF6F | (6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98 | 10mg | $82 | 2026-05-28 | Buy |
| aablocks | AA00FF6F | (6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98 | 25mg | $142 | 2026-05-28 | Buy |
| aablocks | AA00FF6F | (6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98% | 50mg | $189 | 2026-05-28 | Buy |
| aablocks | AA00FF6F | (6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98% | 100mg | $278 | 2026-05-28 | Buy |
| aablocks | AA00FF6F | (6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl (4-(Hydroxycarbamoyl)Phenyl)Carbamate Hydrochloride Hydrate 98% | 250mg | $389 | 2026-05-28 | Buy |
| ACHEMBLOCK | X209266 | Givinostat hydrochloride hydrate 97% | 100MG | $290 | 2026-05-27 | Buy |
| ACHEMBLOCK | X209266 | Givinostat hydrochloride hydrate 97% | 1G | $845 | 2026-05-27 | Buy |
| AK Scientific | X7528 | Givinostat | 50mg | $834 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007793 | ITF2357 95.00% | 5MG | $495.94 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007793 | ITF2357 95.00% | 1MG | $153.3 | 2021-12-16 | Buy |
| ApexBio Technology | A4093 | ITF2357 (Givinostat) | 10mg | $190 | 2026-05-06 | Buy |
| ApexBio Technology | A4093 | ITF2357 (Givinostat) | EvaluationSample | $30 | 2026-05-06 | Buy |
| ApexBio Technology | A4093 | ITF2357 (Givinostat) | 5mg | $110 | 2026-05-06 | Buy |
| ApexBio Technology | A4093 | ITF2357 (Givinostat) | 10mM(in1mLDMSO) | $120 | 2026-05-06 | Buy |
| ApexBio Technology | A4093 | ITF2357(Givinostat) | 50mg | $670 | 2021-12-16 | Buy |
Properties
storage temp. :-20°C
solubility :≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥2.9 mg/mL in H2O with gentle warming and ultrasonic
form :powder
color :white to beige
InChIKey :FKGKZBBDJSKCIS-UHFFFAOYSA-N
SMILES :C(OCC1=CC=C2C(=C1)C=CC(CN(CC)CC)=C2)(=O)NC1=CC=C(C(NO)=O)C=C1.[H]Cl.[H]O[H]
CAS DataBase Reference :732302-99-7
solubility :≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥2.9 mg/mL in H2O with gentle warming and ultrasonic
form :powder
color :white to beige
InChIKey :FKGKZBBDJSKCIS-UHFFFAOYSA-N
SMILES :C(OCC1=CC=C2C(=C1)C=CC(CN(CC)CC)=C2)(=O)NC1=CC=C(C(NO)=O)C=C1.[H]Cl.[H]O[H]
CAS DataBase Reference :732302-99-7
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
ITF 2357 inhibits class I and class II histone deacetylases (maize HDACs: HD2, HD-1B, and HD-1A with IC50s = 7.5-16 nM) and reduces the production of several pro-inflammatory cytokines including TNFα, IL-1α, and IL-1β (IC50s = 10-22 nM). ITF 2357 also has activity against cells expressing janus kinase 2 (JAK2)V617F (IC50s = 1-10 nM), a mutated form of the JAK2 enzyme that is implicated in the pathophysiology of many myeloproliferative diseases, including polycythaemia vera.Related product price
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