IWP-3
|
- $42 - $2590
- Product name: IWP-3
- CAS: 687561-60-0
- MF: C22H17FN4O2S3
- MW: 484.59
- EINECS:200-258-5
- MDL Number:MFCD04457889
- Synonyms:IWP-3;2-[[3-(4-Fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-acetamide;Wnt Inhibitor IWP-3;2-((3-(4-fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide;IWP 3;IWP3;Acetamide, 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-;IWP-3 >=98% (HPLC);2-{[3-(4-fluorophenyl)-4-oxo-3H,4H,6H,7H-thieno[3,2-d]pyrimidin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
50 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Alichem
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solution)
- 1mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA00FHF6
- Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide ≥98%
- Packaging1mg
- Price$42
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FHF6
- Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- Packaging5mg
- Price$92
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FHF6
- Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- Packaging10mg
- Price$145
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FHF6
- Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- Packaging25mg
- Price$283
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FHF6
- Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- Packaging50mg
- Price$451
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FHF6
- Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- Packaging100mg
- Price$715
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD264462
- Product descriptionIWP-3 98%
- Packaging100MG
- Price$1040
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD264462
- Product descriptionIWP-3 98%
- Packaging25MG
- Price$390
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number6566CG
- Product description2-[[3-(4-Fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
- Packaging1mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number687561600
- Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- Packaging25mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number687561600
- Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- Packaging10mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3254
- Product descriptionIWP-3
- Packaging10mg
- Price$229
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC3254
- Product descriptionIWP-3
- Packaging5mg
- Price$131
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC3254
- Product descriptionIWP-3
- Packaging25mg
- Price$494
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberCS-0019680
- Product descriptionIWP-3 >=98%
- Packaging50mg
- Price$488
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberCS-0019680
- Product descriptionIWP-3 >=98%
- Packaging100mg
- Price$788
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00FHF6 | 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide ≥98% | 1mg | $42 | 2026-05-28 | Buy |
| aablocks | AA00FHF6 | 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide | 5mg | $92 | 2026-05-28 | Buy |
| aablocks | AA00FHF6 | 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide | 10mg | $145 | 2026-05-28 | Buy |
| aablocks | AA00FHF6 | 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide | 25mg | $283 | 2026-05-28 | Buy |
| aablocks | AA00FHF6 | 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide | 50mg | $451 | 2026-05-28 | Buy |
| aablocks | AA00FHF6 | 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide | 100mg | $715 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD264462 | IWP-3 98% | 100MG | $1040 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD264462 | IWP-3 98% | 25MG | $390 | 2026-05-27 | Buy |
| AK Scientific | 6566CG | 2-[[3-(4-Fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide | 1mg | $140 | 2021-12-16 | Buy |
| Alichem | 687561600 | 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide | 25mg | $350 | 2021-12-16 | Buy |
| Alichem | 687561600 | 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide | 10mg | $168 | 2021-12-16 | Buy |
| ApexBio Technology | C3254 | IWP-3 | 10mg | $229 | 2026-05-06 | Buy |
| ApexBio Technology | C3254 | IWP-3 | 5mg | $131 | 2026-05-06 | Buy |
| ApexBio Technology | C3254 | IWP-3 | 25mg | $494 | 2026-05-06 | Buy |
| Arctom | CS-0019680 | IWP-3 >=98% | 50mg | $488 | 2026-05-26 | Buy |
| Arctom | CS-0019680 | IWP-3 >=98% | 100mg | $788 | 2026-05-26 | Buy |
Properties
Melting point :>248°C (dec.)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL (clear solution, warmed)
form :powder
color :white to beige
InChI :1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
InChIKey :XVMHQSDMKWQNBK-UHFFFAOYSA-N
SMILES :Cc1ccc2nc(NC(=O)CSC3=NC4=C(SCC4)C(=O)N3c5ccc(F)cc5)sc2c1
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL (clear solution, warmed)
form :powder
color :white to beige
InChI :1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
InChIKey :XVMHQSDMKWQNBK-UHFFFAOYSA-N
SMILES :Cc1ccc2nc(NC(=O)CSC3=NC4=C(SCC4)C(=O)N3c5ccc(F)cc5)sc2c1
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-3 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 40 nM. IWP-3 inactivates porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 μM, IWP-3 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 (LRP6) and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. By inhibiting Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC50 = 1.2 μM).Related product price
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Suppliers and manufacturers
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
AdooQ BioScience, LLC
AdooQ Bioscience CHINA
Sigma-Aldrich
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Shanghai Changyan Chem & Tech Co., Ltd.
Tianjin Kailiqi Biotechnology Co., Ltd.
Medi-tech Bioscientific Co., Ltd.