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ChemicalBook >> CAS DataBase List >> NSC781406

NSC781406

NSC781406 price.
  • $32 - $1200
  • Product name: NSC781406
  • CAS: 1676893-24-5
  • MF: C29H27F2N5O5S2
  • MW: 627.68
  • EINECS:
  • MDL Number:
  • Synonyms:NSC781406;NSC781406;NSC-781406;NSC 781406;NSC-781406;NSC 781406;Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-;NSC781406,Phosphoinositide 3-kinase,NSC 781406,NSC-781406,PI3K,Mammalian target of Rapamycin,Inhibitor,inhibit,mTOR
Price11 Properties Safety Information Description
11 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number5398EJ
  • Product description2,4-Difluoro-N-[2-methoxy-5-[4-[3-(4-methylsulfonylpiperazin-1-yl)prop-1-ynyl]quinolin-6-yl]pyridin-3-yl]benzenesulfonamide
  • Packaging5mg
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29226
  • Product descriptionNSC 781406
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29226
  • Product descriptionNSC 781406
  • Packaging5mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29226
  • Product descriptionNSC 781406
  • Packaging10mg
  • Price$261
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6958
  • Product descriptionNSC781406 99.91%
  • Packaging1mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6958
  • Product descriptionNSC781406 99.91%
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6958
  • Product descriptionNSC781406 99.91%
  • Packaging10mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6958
  • Product descriptionNSC781406 99.91%
  • Packaging50mg
  • Price$600
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6958
  • Product descriptionNSC781406 99.91%
  • Packaging100mg
  • Price$950
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10484
  • Product descriptionNSC781406 >98%
  • Packaging100mg
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10484
  • Product descriptionNSC781406 >98%
  • Packaging250mg
  • Price$1200
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5398EJ 2,4-Difluoro-N-[2-methoxy-5-[4-[3-(4-methylsulfonylpiperazin-1-yl)prop-1-ynyl]quinolin-6-yl]pyridin-3-yl]benzenesulfonamide 5mg $252 2021-12-16 Buy
Cayman Chemical 29226 NSC 781406 1mg $32 2024-03-01 Buy
Cayman Chemical 29226 NSC 781406 5mg $139 2024-03-01 Buy
Cayman Chemical 29226 NSC 781406 10mg $261 2024-03-01 Buy
ChemScene CS-6958 NSC781406 99.91% 1mg $60 2021-12-16 Buy
ChemScene CS-6958 NSC781406 99.91% 5mg $120 2021-12-16 Buy
ChemScene CS-6958 NSC781406 99.91% 10mg $200 2021-12-16 Buy
ChemScene CS-6958 NSC781406 99.91% 50mg $600 2021-12-16 Buy
ChemScene CS-6958 NSC781406 99.91% 100mg $950 2021-12-16 Buy
DC Chemicals DC10484 NSC781406 >98% 100mg $700 2021-12-16 Buy
DC Chemicals DC10484 NSC781406 >98% 250mg $1200 2021-12-16 Buy

Properties

Boiling point :775.1±70.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 10mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
form :A solid
pka :6.23±0.40(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

NSC 781406 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC50s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively). It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 65 nM). NSC 781406 (30 mg/kg) reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model.

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