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ChemicalBook >> CAS DataBase List >> RAF709

RAF709

RAF709 price.
  • $35 - $1800
  • Product name: RAF709
  • CAS: 1628838-42-5
  • MF: C28H29F3N4O4
  • MW: 542.55
  • EINECS:
  • MDL Number:MFCD30534393
  • Synonyms:RAF709;CS-2505;RAF-709;RAF 709;Benzamide, N-[2-methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)-;N-[2-Methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)benzamide;Inhibitor,inhibit,Raf,Raf kinases,RAF709,RAF-709,RAF 709;N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide;RAF709, 10 mM in DMSO
Price34 Properties Safety Information Description
34 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Apolloscientific
  • Arctom
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 10mM*1mLinDMSO
  • 1mg
  • 5mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 10mM*1mLinDMSO(Solution)
  • Manufactureraablocks
  • Product numberAA00ASQX
  • Product descriptionN-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98%
  • Packaging1mg
  • Price$45
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ASQX
  • Product descriptionN-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98%
  • Packaging5mg
  • Price$54
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ASQX
  • Product descriptionN-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98%
  • Packaging10mg
  • Price$74
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ASQX
  • Product descriptionN-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98%
  • Packaging25mg
  • Price$95
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ASQX
  • Product descriptionN-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98%
  • Packaging50mg
  • Price$124
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ASQX
  • Product descriptionN-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98%
  • Packaging100mg
  • Price$209
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberS72373
  • Product descriptionRAF-709 98%
  • Packaging25MG
  • Price$150
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberS72373
  • Product descriptionRAF-709 98%
  • Packaging100MG
  • Price$270
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number3613EB
  • Product descriptionN-[6-Methyl-5-[5-morpholin-4-yl-6-(oxan-4-yloxy)pyridin-3-yl]pyridin-3-yl]-3-(trifluoromethyl)benzamide
  • Packaging10mg
  • Price$455
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0207
  • Product descriptionRAF709
  • Packaging1mg
  • Price$35
  • Updated2026-06-04
  • Buy
  • ManufacturerArctom
  • Product numberHY-100510
  • Product descriptionRAF709 99.92%
  • Packaging10mM*1mLinDMSO(Solution)
  • Price$113
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-100510
  • Product descriptionRAF709 99.92%
  • Packaging10mM*1mLinDMSO(Solid+Solvent)
  • Price$107
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-100510
  • Product descriptionRAF709 99.92%
  • Packaging5mg
  • Price$95
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-100510
  • Product descriptionRAF709 99.92%
  • Packaging10mg
  • Price$157
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S8690
  • Product descriptionRAF709 99.86%
  • Packaging5mg
  • Price$140
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-100510
  • Product descriptionRAF709 99.92%
  • Packaging50mg
  • Price$513
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00ASQX N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98% 1mg $45 2026-05-28 Buy
aablocks AA00ASQX N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98% 5mg $54 2026-05-28 Buy
aablocks AA00ASQX N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98% 10mg $74 2026-05-28 Buy
aablocks AA00ASQX N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98% 25mg $95 2026-05-28 Buy
aablocks AA00ASQX N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98% 50mg $124 2026-05-28 Buy
aablocks AA00ASQX N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 98% 100mg $209 2026-05-28 Buy
ACHEMBLOCK S72373 RAF-709 98% 25MG $150 2026-05-27 Buy
ACHEMBLOCK S72373 RAF-709 98% 100MG $270 2026-05-27 Buy
AK Scientific 3613EB N-[6-Methyl-5-[5-morpholin-4-yl-6-(oxan-4-yloxy)pyridin-3-yl]pyridin-3-yl]-3-(trifluoromethyl)benzamide 10mg $455 2021-12-16 Buy
Apolloscientific BISN0207 RAF709 1mg $35 2026-06-04 Buy
Arctom HY-100510 RAF709 99.92% 10mM*1mLinDMSO(Solution) $113 2026-05-26 Buy
Arctom HY-100510 RAF709 99.92% 10mM*1mLinDMSO(Solid+Solvent) $107 2026-05-26 Buy
Arctom HY-100510 RAF709 99.92% 5mg $95 2026-05-26 Buy
Arctom HY-100510 RAF709 99.92% 10mg $157 2026-05-26 Buy
Arctom SLK-S8690 RAF709 99.86% 5mg $140 2026-05-26 Buy
Arctom HY-100510 RAF709 99.92% 50mg $513 2026-05-26 Buy
Next Last

Properties

Boiling point :622.7±55.0 °C(Predicted)
Density :1.321±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:100.0(Max Conc. mg/mL);184.31(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.61(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);55.29(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);184.31(Max Conc. mM) form :A crystalline solid
pka :11.87±0.70(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

RAF709 is a potent inhibitor of B-RAF and C-RAF (IC50s = 0.4 and 0.5 nM, respectively). It is selective for RAF kinases exhibiting >99% inhibition of only B-RAF, B-RAFV600E, and C-RAF in a panel of 456 kinases. However, DDR1, DDR2, FRK, and PDGFRβ are also inhibited by >80% at a concentration of 1 μM. RAF709 inhibits phosphorylation of MEK and ERK (EC50s = 0.02 and 0.1 μM, respectively) with minimal paradoxical activation, stabilizes BRAF-CRAF dimers (EC50 = 0.8 μM), and reduces proliferation of Calu-6 RAS mutant cells (EC50 = 0.95 μM). In a Calu-6 mouse non-small cell lung cancer (NSCLC) xenograft model, RAF709 (10-200 mg/kg) reduces ERK phosphorylation and decreases tumor volume in a dose-dependent manner without affecting total body weight.

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Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. Bide Pharmatech Ltd. AdooQ Bioscience CHINA Shanghai Lollane Biological Technology Co.,Ltd. Shanghaizehan biopharma technology co., Ltd. Shanghai EFE Biological Technology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. ShangHai Biochempartner Co.,Ltd Shanghai Rechem science Co., Ltd. Shanghai Chaolan Chemical Technology Center