SP 141
|
- $49 - $2995
- Product name: SP 141
- CAS: 1253491-42-7
- MF: C22H16N2O
- MW: 324.38
- EINECS:
- MDL Number:MFCD29059920
- Synonyms:SP 141;6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole;9H-Pyrido[3,4-b]indole, 6-methoxy-1-(1-naphthalenyl)-;SP 141;SP141;;6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole;6-Methoxy-1-(1-naphthyl)-9H-β-carboline;pancreatic,SP-141,inhibit,Inhibitor,cancer,MDM-2/p53,breast,degradation,auto-ubiquitination,SP141;SP-141, 10 mM in DMSO
46 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 50
- 1mg
- 5mg
- 10mM*1mLinDMSO(Solution)
- 10mg
- 10
- 25mg
- 50mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA01E0KK
- Product descriptionSp 141 ≥98%
- Packaging1mg
- Price$49
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0KK
- Product descriptionSp 141
- Packaging5mg
- Price$88
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0KK
- Product descriptionSp 141
- Packaging10mg
- Price$124
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0KK
- Product descriptionSp 141
- Packaging25mg
- Price$231
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0KK
- Product descriptionSp 141 98%
- Packaging50mg
- Price$247
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0KK
- Product descriptionSp 141 ≥98%(HPLC)
- Packaging100mg
- Price$250
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0KK
- Product descriptionSp 141 98%
- Packaging250mg
- Price$452
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0KK
- Product descriptionSp 141 98%
- Packaging1g
- Price$1342
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberU109991
- Product descriptionSP141 98.00%
- Packaging1G
- Price$1035
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU109991
- Product descriptionSP141 98.00%
- Packaging100MG
- Price$205
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number5674DP
- Product description6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole
- Packaging1mg
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number5674DP
- Product description6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole
- Packaging10mg
- Price$313
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4120
- Product descriptionSP 141
- Packaging50mg
- Price$770
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC4120
- Product descriptionSP 141
- Packaging5mg
- Price$131
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC4120
- Product descriptionSP 141
- Packaging10mg
- Price$209
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-110182
- Product descriptionSP-141 98.93%
- Packaging10mg
- Price$152
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01E0KK | Sp 141 ≥98% | 1mg | $49 | 2026-05-30 | Buy |
| aablocks | AA01E0KK | Sp 141 | 5mg | $88 | 2026-05-30 | Buy |
| aablocks | AA01E0KK | Sp 141 | 10mg | $124 | 2026-05-30 | Buy |
| aablocks | AA01E0KK | Sp 141 | 25mg | $231 | 2026-05-30 | Buy |
| aablocks | AA01E0KK | Sp 141 98% | 50mg | $247 | 2026-05-30 | Buy |
| aablocks | AA01E0KK | Sp 141 ≥98%(HPLC) | 100mg | $250 | 2026-05-30 | Buy |
| aablocks | AA01E0KK | Sp 141 98% | 250mg | $452 | 2026-05-30 | Buy |
| aablocks | AA01E0KK | Sp 141 98% | 1g | $1342 | 2026-05-30 | Buy |
| ACHEMBLOCK | U109991 | SP141 98.00% | 1G | $1035 | 2026-05-27 | Buy |
| ACHEMBLOCK | U109991 | SP141 98.00% | 100MG | $205 | 2026-05-27 | Buy |
| AK Scientific | 5674DP | 6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole | 1mg | $147 | 2021-12-16 | Buy |
| AK Scientific | 5674DP | 6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole | 10mg | $313 | 2021-12-16 | Buy |
| ApexBio Technology | C4120 | SP 141 | 50mg | $770 | 2026-05-06 | Buy |
| ApexBio Technology | C4120 | SP 141 | 5mg | $131 | 2026-05-06 | Buy |
| ApexBio Technology | C4120 | SP 141 | 10mg | $209 | 2026-05-06 | Buy |
| Arctom | HY-110182 | SP-141 98.93% | 10mg | $152 | 2026-05-26 | Buy |
Properties
Boiling point :571.2±45.0 °C(Predicted)
Density :1.284±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤100mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form :crystalline solid
pka :15.04±0.40(Predicted)
color :White to yellow
InChI :1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3
InChIKey :AABFWJDLCCDJJN-UHFFFAOYSA-N
SMILES :COC1=CC=C(NC2=C3C=CN=C2C4=CC=CC5=C4C=CC=C5)C3=C1
Density :1.284±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤100mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form :crystalline solid
pka :15.04±0.40(Predicted)
color :White to yellow
InChI :1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3
InChIKey :AABFWJDLCCDJJN-UHFFFAOYSA-N
SMILES :COC1=CC=C(NC2=C3C=CN=C2C4=CC=CC5=C4C=CC=C5)C3=C1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Mouse double minute 2 protein (Mdm2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP 141 is a cell-permeable inhibitor of Mdm2 (Ki = 28 nM). Binding of Mdm2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation. SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo. This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.More related product prices
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