Sivelestat
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- $18 - $1900
- Product name: Sivelestat
- CAS: 127373-66-4
- MF: C20H22N2O7S
- MW: 434.46
- EINECS:
- MDL Number:MFCD00889071
- Synonyms:EI 546 sodium salt hydrate;Elaspol sodium salt hydrate;LY 544349 sodium salt hydrate;o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester) sodium salt hydrate;Ono-5046 sodium salt hydrate;Sivelestat (ONO-5046);2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid;n-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)glycine
62 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Activate Scientific
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Synthonix
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mg
- 50mg
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 25mg
- 100.00mg
- 100mg
- 200mg
- 250.00mg
- 250mg
- 1.00g
- 1g
- 5g
- Manufactureraablocks
- Product numberAA000WX4
- Product descriptionSivelestat 98%(HPLC)
- Packaging1mg
- Price$18
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000WX4
- Product descriptionSivelestat ≥98%(HPLC)
- Packaging5mg
- Price$27
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000WX4
- Product descriptionSivelestat ≥98%(HPLC)
- Packaging25mg
- Price$54
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000WX4
- Product descriptionSivelestat 98%
- Packaging100mg
- Price$71
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000WX4
- Product descriptionSivelestat 98%
- Packaging250mg
- Price$113
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000WX4
- Product descriptionSivelestat ≥98%(HPLC)
- Packaging1g
- Price$343
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000WX4
- Product descriptionSivelestat ≥98%(HPLC)
- Packaging5g
- Price$1212
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238797
- Product descriptionSivelestat 98%
- Packaging250MG
- Price$115
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238797
- Product descriptionSivelestat 98%
- Packaging1G
- Price$210
- Updated2026-05-27
- Buy
- ManufacturerActivate Scientific
- Product numberAS148193
- Product descriptionSivelestat 98%
- Packaging5G
- Price$1332
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS148193
- Product descriptionSivelestat 98%
- Packaging1g
- Price$381
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberP528
- Product descriptionSivelestat
- Packaging5mg
- Price$367
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA310710
- Product descriptionSivelestat 98+%
- Packaging1g
- Price$284
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA310710
- Product descriptionSivelestat 98+%
- Packaging5g
- Price$1001
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA310710
- Product descriptionSivelestat 98+%
- Packaging250mg
- Price$112
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000053
- Product descriptionSIVELESTAT 95.00%
- Packaging5G
- Price$1754.55
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000WX4 | Sivelestat 98%(HPLC) | 1mg | $18 | 2026-05-25 | Buy |
| aablocks | AA000WX4 | Sivelestat ≥98%(HPLC) | 5mg | $27 | 2026-05-25 | Buy |
| aablocks | AA000WX4 | Sivelestat ≥98%(HPLC) | 25mg | $54 | 2026-05-25 | Buy |
| aablocks | AA000WX4 | Sivelestat 98% | 100mg | $71 | 2026-05-25 | Buy |
| aablocks | AA000WX4 | Sivelestat 98% | 250mg | $113 | 2026-05-25 | Buy |
| aablocks | AA000WX4 | Sivelestat ≥98%(HPLC) | 1g | $343 | 2026-05-25 | Buy |
| aablocks | AA000WX4 | Sivelestat ≥98%(HPLC) | 5g | $1212 | 2026-05-25 | Buy |
| ACHEMBLOCK | Z238797 | Sivelestat 98% | 250MG | $115 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238797 | Sivelestat 98% | 1G | $210 | 2026-05-27 | Buy |
| Activate Scientific | AS148193 | Sivelestat 98% | 5G | $1332 | 2021-12-16 | Buy |
| Activate Scientific | AS148193 | Sivelestat 98% | 1g | $381 | 2021-12-16 | Buy |
| AK Scientific | P528 | Sivelestat | 5mg | $367 | 2021-12-16 | Buy |
| Ambeed | A310710 | Sivelestat 98+% | 1g | $284 | 2021-12-16 | Buy |
| Ambeed | A310710 | Sivelestat 98+% | 5g | $1001 | 2021-12-16 | Buy |
| Ambeed | A310710 | Sivelestat 98+% | 250mg | $112 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000053 | SIVELESTAT 95.00% | 5G | $1754.55 | 2021-12-16 | Buy |
Properties
Melting point :218-220°
Density :1.369±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :White to off-white solid
pka :3.67±0.10(Predicted)
color :white to off-white
InChI :InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChIKey :BTGNGJJLZOIYID-UHFFFAOYSA-N
SMILES :C(OC1=CC=C(S(NC2=CC=CC=C2C(NCC(O)=O)=O)(=O)=O)C=C1)(=O)C(C)(C)C
Density :1.369±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :White to off-white solid
pka :3.67±0.10(Predicted)
color :white to off-white
InChI :InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChIKey :BTGNGJJLZOIYID-UHFFFAOYSA-N
SMILES :C(OC1=CC=C(S(NC2=CC=CC=C2C(NCC(O)=O)=O)(=O)=O)C=C1)(=O)C(C)(C)C
Safety Information
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Description
Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Sivelestat displays >100-fold greater selectivity over pancreas elastase (IC50 = 5.6 μM). Sivelestat does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 μM. Sivelestat effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability. Sivelestat is also reported to inhibit mast cell Stat6-protease.More related product prices
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Suppliers and manufacturers
Changzhou Chenhong Biotechnology Co., Ltd.
Hangzhou Xiao Bei Medical Technology Co., LTD
Lanzhou Dawnrays Pharmaceutical Co Ltd
Chembest Research Laboratories Limited
Adamas Reagent, Ltd.
China Langchem Inc.
BOC Sciences
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Shanghai Arbor Chemical Co., Ltd.
MedChemexpress LLC