THIOSTREPTON
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- $6 - $1238
- Product name: THIOSTREPTON
- CAS: 1393-48-2
- MF: C72H85N19O18S5
- MW: 1664.89
- EINECS:215-734-9
- MDL Number:MFCD00135828
- Synonyms:Thiostrepton (200 mg);BryaMycin, Thiactin, AlaninaMide, X 146, A 8506, 6761-31;Thiostrepton, froM StreptoMyces sp.;x146 ;THIOSTREPTON;Alaninamide, L-threonyl-(4S)-2-(1Z)-1-amino-1-propenyl-4,5-dihydro-4-thiazolecarbonyl-2-(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl-4-thiazolecarbonyl-2-(5R,6S)-6-2-(1S,2R)-1-amino-2-hydroxypropyl-4-thiazolyl-5-N-(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy;THIOSTREPTION;thiostrepton from streptomyces azureus
60 prices
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Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- Matrix Scientific
- Sigma-Aldrich
- Thermo Scientific Chemicals
- Tocris
- TRC
- Usbiological
Package
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- 1mg
- 10mg
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- 100mg
- 100.00mg
- 250mg
- 250.00mg
- 0.5g
- 500mg
- 1.00g
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- 2g
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- 5g
- 10g
- Manufactureraablocks
- Product numberAA006XK6
- Product descriptionThiostrepton 98%
- Packaging1mg
- Price$9
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006XK6
- Product descriptionThiostrepton 98%
- Packaging10mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006XK6
- Product descriptionThiostrepton 98%
- Packaging50mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006XK6
- Product descriptionThiostrepton 98%
- Packaging100mg
- Price$41
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006XK6
- Product descriptionThiostrepton 98%
- Packaging250mg
- Price$68
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006XK6
- Product descriptionThiostrepton ≥95%
- Packaging500mg
- Price$76
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006XK6
- Product descriptionThiostrepton ≥95%
- Packaging1g
- Price$115
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006XK6
- Product descriptionThiostrepton ≥95%
- Packaging5g
- Price$494
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238342
- Product descriptionThiostrepton 98%
- Packaging5G
- Price$925
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238342
- Product descriptionThiostrepton 98%
- Packaging250MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238342
- Product descriptionThiostrepton 98%
- Packaging1G
- Price$265
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA265605
- Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
- Packaging250mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA265605
- Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
- Packaging1mg
- Price$6
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA265605
- Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
- Packaging50mg
- Price$32
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA265605
- Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
- Packaging10mg
- Price$14
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0004400
- Product descriptionThiostrepton 95.00%
- Packaging1G
- Price$693.92
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA006XK6 | Thiostrepton 98% | 1mg | $9 | 2026-05-28 | Buy |
| aablocks | AA006XK6 | Thiostrepton 98% | 10mg | $12 | 2026-05-28 | Buy |
| aablocks | AA006XK6 | Thiostrepton 98% | 50mg | $27 | 2026-05-28 | Buy |
| aablocks | AA006XK6 | Thiostrepton 98% | 100mg | $41 | 2026-05-28 | Buy |
| aablocks | AA006XK6 | Thiostrepton 98% | 250mg | $68 | 2026-05-28 | Buy |
| aablocks | AA006XK6 | Thiostrepton ≥95% | 500mg | $76 | 2026-05-28 | Buy |
| aablocks | AA006XK6 | Thiostrepton ≥95% | 1g | $115 | 2026-05-28 | Buy |
| aablocks | AA006XK6 | Thiostrepton ≥95% | 5g | $494 | 2026-05-28 | Buy |
| ACHEMBLOCK | Z238342 | Thiostrepton 98% | 5G | $925 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238342 | Thiostrepton 98% | 250MG | $110 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238342 | Thiostrepton 98% | 1G | $265 | 2026-05-27 | Buy |
| Ambeed | A265605 | N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% | 250mg | $70 | 2021-12-16 | Buy |
| Ambeed | A265605 | N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% | 1mg | $6 | 2021-12-16 | Buy |
| Ambeed | A265605 | N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% | 50mg | $32 | 2021-12-16 | Buy |
| Ambeed | A265605 | N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% | 10mg | $14 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004400 | Thiostrepton 95.00% | 1G | $693.92 | 2021-12-16 | Buy |
Properties
Melting point :248-257°C (dec.)
alpha :D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
Density :1.0824 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO or chloroform
form :Off-white powder
pka :10.43±0.46(Predicted)
color :Off-white
Water Solubility :0.24g/L(28 ºC)
Merck :13,9440
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey :NSFFHOGKXHRQEW-MRQRIGNGNA-N
alpha :D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
Density :1.0824 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO or chloroform
form :Off-white powder
pka :10.43±0.46(Predicted)
color :Off-white
Water Solubility :0.24g/L(28 ºC)
Merck :13,9440
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey :NSFFHOGKXHRQEW-MRQRIGNGNA-N
Safety Information
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| Signal word: | Warning | |||||||
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Description
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells. These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.Related product price
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