macitentan
|
- $39 - $2397
- Product name: macitentan
- CAS: 441798-33-0
- MF: C19H20Br2N6O4S
- MW: 588.27
- EINECS:1308068-626-2
- MDL Number:MFCD17167076
- Synonyms:N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)-oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfami;macitentan;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide;ACT 064992;ACT-064992;ACT-064992 / ACT064992;Macitentan, >=99%;SulfaMide,N-[5-(4-broMophenyl)-6-[2-[(5-broMo-2-pyriMidinyl)oxy]ethoxy]-4-pyriMidinyl]-N'-propyl-
56 prices
Selected condition：
Brand
- AccelPharmtech
- AK Scientific
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Labseeker
- Matrix Scientific
- Medical Isotopes, Inc.
Package
- 10mg
- 10mM*1mLinDMSO
- 5mg
- 25mg
- 50mg
- 100mg
- 250mg
- 250.00mg
- 500mg
- 1.00g
- 10mM*1mLinDMSO(Solution)
- 1G
- 5.00g
- 10mM(in1mLDMSO)
- 5G
- 10g
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(1mLinDMSO)
- ManufacturerAccelPharmtech
- Product numberAT8268
- Product descriptionMacitentan 99%
- Packaging1G
- Price$150
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberAT8268
- Product descriptionMacitentan 99%
- Packaging5G
- Price$380
- Updated2026-05-21
- Buy
- ManufacturerAK Scientific
- Product numberX6162
- Product descriptionMacitentan
- Packaging100mg
- Price$2397
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1929
- Product descriptionMacitentan
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1929
- Product descriptionMacitentan
- Packaging5mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1929
- Product descriptionMacitentan
- Packaging10mM(in1mLDMSO)
- Price$70
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1929
- Product descriptionMacitentan
- Packaging25mg
- Price$95
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1929
- Product descriptionMacitentan
- Packaging100mg
- Price$190
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-14184
- Product descriptionMacitentan 99.85%
- Packaging100mg
- Price$157
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14184R
- Product descriptionMacitentan (Standard) 99.79%
- Packaging10mg
- Price$181
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S8051
- Product descriptionMacitentan (ACT 064992) 99.98%
- Packaging10mM(1mLinDMSO)
- Price$188
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14184
- Product descriptionMacitentan 99.85%
- Packaging50mg
- Price$105
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14184R
- Product descriptionMacitentan (Standard) 99.79%
- Packaging5mg
- Price$129
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S8051
- Product descriptionMacitentan (ACT 064992) 99.98%
- Packaging5mg
- Price$140
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14184
- Product descriptionMacitentan 99.85%
- Packaging10mg
- Price$74
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14184
- Product descriptionMacitentan 99.85%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$64
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AccelPharmtech | AT8268 | Macitentan 99% | 1G | $150 | 2026-05-21 | Buy |
| AccelPharmtech | AT8268 | Macitentan 99% | 5G | $380 | 2026-05-21 | Buy |
| AK Scientific | X6162 | Macitentan | 100mg | $2397 | 2021-12-16 | Buy |
| ApexBio Technology | A1929 | Macitentan | 5mg | $55 | 2021-12-16 | Buy |
| ApexBio Technology | A1929 | Macitentan | 5mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | A1929 | Macitentan | 10mM(in1mLDMSO) | $70 | 2026-05-06 | Buy |
| ApexBio Technology | A1929 | Macitentan | 25mg | $95 | 2026-05-06 | Buy |
| ApexBio Technology | A1929 | Macitentan | 100mg | $190 | 2026-05-06 | Buy |
| Arctom | HY-14184 | Macitentan 99.85% | 100mg | $157 | 2026-05-26 | Buy |
| Arctom | HY-14184R | Macitentan (Standard) 99.79% | 10mg | $181 | 2026-05-26 | Buy |
| Arctom | SLK-S8051 | Macitentan (ACT 064992) 99.98% | 10mM(1mLinDMSO) | $188 | 2026-05-26 | Buy |
| Arctom | HY-14184 | Macitentan 99.85% | 50mg | $105 | 2026-05-26 | Buy |
| Arctom | HY-14184R | Macitentan (Standard) 99.79% | 5mg | $129 | 2026-05-26 | Buy |
| Arctom | SLK-S8051 | Macitentan (ACT 064992) 99.98% | 5mg | $140 | 2026-05-26 | Buy |
| Arctom | HY-14184 | Macitentan 99.85% | 10mg | $74 | 2026-05-26 | Buy |
| Arctom | HY-14184 | Macitentan 99.85% | 10mM*1mLinDMSO(Solid+Solvent) | $64 | 2026-05-26 | Buy |
Properties
Boiling point :692.4±65.0 °C(Predicted)
Density :1.675
storage temp. :Store at -20°C
solubility :≥24.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :4.99±0.50(Predicted)
color :White to off-white
InChI :InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)
InChIKey :JGCMEBMXRHSZKX-UHFFFAOYSA-N
SMILES :S(NC1C(C2=CC=C(Br)C=C2)=C(OCCOC2=NC=C(Br)C=N2)N=CN=1)(NCCC)(=O)=O
Density :1.675
storage temp. :Store at -20°C
solubility :≥24.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :4.99±0.50(Predicted)
color :White to off-white
InChI :InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)
InChIKey :JGCMEBMXRHSZKX-UHFFFAOYSA-N
SMILES :S(NC1C(C2=CC=C(Br)C=C2)=C(OCCOC2=NC=C(Br)C=N2)N=CN=1)(NCCC)(=O)=O
Safety Information
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Description
Macitentan (also known as ACT-064992) received US FDA approval in October 2013 for the treatment of pulmonary arterial hypertension (PAH) (WHO group I) to delay disease progression. Treatment options include phosphodiesterase type 5 inhibitors, prostacyclins, and the endothelin receptor antagonists bosentan and ambrisentan. Macitentan was discovered through SAR studies starting with the bosentan structure with three main goals: (1) to increase potency for both endothelin receptor A and B (ETA and ETB) subtypes; (2) to improve tissue distribution to reach the target receptors; and (3) to avoid bile salt transport inhibition. Starting with the bosentan sulfonamido-pyrimidinyl central core, potency was increased 10-fold via incorporation of a bromopyrimidinyl ethylene glycol ether, as found in the clinical endothelin antagonist, T-0201. An aryl ether in bosentan was replaced with the bromophenyl group in macitentan, and a substituent on the 2-position of the central pyrimidine was replaced with hydrogen. Several sulfonamides and alkyl sulfamates were explored, with the propylsulfamate providing the best combination of in vitro potency, especially for ETB antagonism, and in vivo efficacy.Related product price
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$30-1802
Suppliers and manufacturers
Seasons Biotechnology Co., Ltd.
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Capot Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.
Shanghai Yingrui Biopharma Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
