美洛培南三水合物
中文名称 | 美洛培南三水合物 |
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中文同义词 | 美罗培南(标准品);美罗培南三水合物;美罗培南三水;3-[5-(二甲基氨基甲酰基)哌啶-3-基]硫基]-6-(1-羟乙基)-4-甲基-7-氧代-1-氮杂二环[3.2.0]庚-2-烯-2-甲酸三水合物;美罗培南纯粉;美洛培南三水;美洛培南三水合物;美洛培南 |
英文名称 | Meropenem Trihydrate |
英文同义词 | 3-(5-Dimethylcarbamoyl-pyrrolidin-3-ylsulfanyl)-6-(1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicy;(1R,5S,6S)-2-[(3S,5S)-5-(dimethylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid trihydrate;(4R,5S,6S)-3-{[(3S,5S)-5-(diMethylcarbaMoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;(4R,5S,6S)-3-[[(3S,5S)-5-[(DiMeth-ylaMino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate;(4R, 5S, 6S)-3-((3S, 5S)-5-(DIMETHYLCARBAMOYL)-3-PYRROLIDINYL) THIO)-6-((1R)-1-HYDROXYETHYL)-4-METHYL-;(4R,5S,6S)-3-(((3S,5S)-5-(diMethylcarbaMoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-Methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;MeropeneM USP trihydrate;1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid,3-[[(3S,5S)-5-[(diMethylaMino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-,hydrate (1:3), (4R,5S,6S)- |
CAS号 | 119478-56-7 |
分子式 | C17H27N3O6S |
分子量 | 401.48 |
EINECS号 | 1312995-182-4 |
相关类别 | 抗生素及抗病毒;抗生素;原料药;医药 抗生素;医药原料药-科研原料;医药原料;原料;其他生化试剂;医药原料;API;化学试剂;精细化工原料;医用原料;化工品;化药杂质-美罗培南;化工;试剂;119478-56-7;工业化;对照品 |
Mol文件 | 119478-56-7.mol |
结构式 |
美洛培南三水合物 性质
熔点 | >192°C (dec.) |
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比旋光度 | -17~-21゜(d/20℃)(c=0.5,H2O)(calculated on the dehydrous basis) |
沸点 | 627℃ |
RTECS号 | CL5446509 |
闪点 | >110°(230°F) |
储存条件 | -20°C |
溶解度 | 溶于水溶液约 5mg/ml |
形态 | 粉末 |
颜色 | 白色至类白色 |
Merck | 14,5900 |
InChIKey | DMJNNHOOLUXYBV-PQTSNVLCSA-N |
SMILES | C(C1=C([C@H](C)[C@]2([H])[C@@]([H])([C@H](O)C)C(=O)N12)S[C@@H]1CN[C@H](C(=O)N(C)C)C1)(=O)O.O |&1:3,5,7,9,16,19,r| |
CAS 数据库 | 119478-56-7(CAS DataBase Reference) |
Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia.
Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection.
Animal Model: | Male Sprague-Dawley rats (250-350 g) induced acute necrotizing pancreatitis |
Dosage: | 60 mg/kg |
Administration: | Intraperitoneal injection; once |
Result: | Significantly reduced the incidence of pancreatic infection. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | 46281 | 美罗培南三水 Meropenem trihydrate | 119478-56-7 | 1g | 779元 |
2024/08/19 | 46281 | 美罗培南三水 Meropenem trihydrate | 119478-56-7 | 5g | 2922元 |