N-羟基-N'-3-吡啶基辛二酰胺
中文名称 | N-羟基-N'-3-吡啶基辛二酰胺 |
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中文同义词 | N-羟基-N'-3-吡啶基辛二酰胺;N-羟基-N'-3-吡啶基辛二酰胺;N1-羟基-N8-(吡啶-3-基)辛二酰胺 |
英文名称 | Pyroxamide |
英文同义词 | 2-[1-carbaMoyl-N-(2H-pyran-2-yl)forMaMido]-N-hydroxy-N'-(pyridin-3-yl)octanediaMide;PyroxaMide (NSC 696085);N1-Hydroxy-N8-3-pyridinyl-octanediamide;N1-Hydroxy-N8-(pyridin-3-yl)octanediamide;Octanediamide, N1-hydroxy-N8-3-pyridinyl-;N-Hydroxy-N'-3-pyridinyloctanediamide;Pyroxamide;PYROXAMIDE, N-HYDROXY-N'-3-PYRIDINYLOCTANEDIAMIDE |
CAS号 | 382180-17-8 |
分子式 | C13H19N3O3 |
分子量 | 265.31 |
EINECS号 | |
相关类别 | 标准品 |
Mol文件 | 382180-17-8.mol |
结构式 |
N-羟基-N'-3-吡啶基辛二酰胺 性质
储存条件 | -20°C |
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溶解度 | DMSO:可溶10mg/mL(澄清溶液) |
形态 | 粉末 |
颜色 | 白色至米色 |
Pyroxamide 是一种有效的组蛋白脱乙酰基酶 1 (HDAC1) 抑制剂,ID50 为 100 nM。 Pyroxamide 可以诱导白血病细胞凋亡和细胞周期停滞。
ID50: 100 nM
Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture. Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1 fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively.
Cell Viability Assay
Cell Line: | RD cells; RH30B cells |
Concentration: | 1.25-20.0 μM |
Incubation Time: | 24 hours; 48 hours; 72 hours |
Result: | Resulted in a cell growth decrease in RD and RH30B cells. |
Cell Cycle Analysis
Cell Line: | RD cells; RH30B cells |
Concentration: | 10.0 μM; 20.0 μM |
Incubation Time: | 48 hours |
Result: | Increased the sub-G1 fractions at 48 hours compared with control samples. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-13216 | N-羟基-N'-3-吡啶基辛二酰胺 Pyroxamide | 382180-17-8 | 5mg | 500元 |
2024/08/19 | HY-13216 | N-羟基-N'-3-吡啶基辛二酰胺 Pyroxamide | 382180-17-8 | 10mM * 1mLin DMSO | 550元 |