短杆菌肽
| 中文名称 | 短杆菌肽 |
|---|---|
| 中文同义词 | GRAMICIDIN (TECHNICAL GRADE);短杆菌肽 EP标准品;短杆菌肽 USP标准品;VG-16;短杆菌肽A;E2970 GRAMICIDIN FROM BACILLUANEURINOLYTICU短杆菌肽 |
| 英文名称 | GRAMICIDIN |
| 英文同义词 | gramicidin from bacillus brevis*(gramicidin D);Gramicidin micronized USP23;GramicidinN.F.Xiv;gramicidin from bacillus aneurinolyticus (bacillus brevis);GRAMICIDIN,USP;GRAMACIDIN D;GRAMICIDIN;GRAMICIDIN D [DUBOS] |
| CAS号 | 1405-97-6 |
| 分子式 | C99H140N20O17 |
| 分子量 | 1882.2947 |
| EINECS号 | 215-790-4 |
| 相关类别 | 微生物代谢物;小分子抑制剂;化工;目录多肽;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics G-MAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;Mechanism of Action;Peptides;Spectrum of Activity;PeptidesMulti-Drug Resistance;Substrates for Drug Efflux PumpsMore...Close...;Drug Efflux Pumps |
| Mol文件 | 1405-97-6.mol |
| 结构式 |  |
短杆菌肽 性质
| 熔点 | 229-230℃ |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 几乎不溶于水，溶于甲醇，微溶于乙醇 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in acetic acid and lower alcohols. Practically insoluble in water. |
| InChIKey | ZWCXYZRRTRDGQE-SORVKSEFSA-N |
| CAS 数据库 | 1405-97-6 |
Gramicidin 是一种抗菌肽，组装成膜中的通道并增加其对阳离子的渗透性。
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
Bacterial
Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations. There is poor Gramicidin activity against E. coli and S. cerevisae as shown from the survival of microbes (%) over a range of Gramicidin concentrations, in contrast with the action of Gramicidin on S. aureus . The microbicidal activity occurs over a range of low Gramicidin and DODAB concentrations which are not toxic to S. cerevisae .
参考质量标准
外观性状:白色粉末纯度(HPLC):≥98.0%醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 20/21-36/37/38 |
| 安全说明 | 26-36-24/25-22 |
| WGK Germany | 3 |
| RTECS号 | MD8225000 |
| 海关编码 | 2941906000 |
| 毒性 | mouse,LD50,intravenous,1500ug/kg (1.5mg/kg),Science. Vol. 103, Pg. 419, 1946. |
| 提供商 | 语言 |
|---|---|
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英文
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