乙胺痉平
中文名称 | 乙胺痉平 |
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中文同义词 | 贝那替秦;苯羟乙胺盐酸盐;胃乐康;乙胺痉平;盐酸贝那替秦;盐酸苯那辛;盐酸贝那替嗪;2-(二乙氨基)乙基二苯乙醇酸酯 盐酸盐 |
英文名称 | BENACTYZINE HYDROCHLORIDE |
英文同义词 | 2-(diethylamino)-ethanobenzilatehydrochloride;2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid;Benactyzine HCL;BENACTYZINE HYDROCHLORIDE 98+%;BENACTYCIN HYDROCHLORIDE;2-(Diethylamino)ethyl benzilate hydrochloride, Benactyzine, α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester;Amizyl;2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid [czech] |
CAS号 | 57-37-4 |
分子式 | C20H26ClNO3 |
分子量 | 363.88 |
EINECS号 | 200-324-4 |
相关类别 | 小分子抑制剂;医药中间体;小分子抑制剂,天然产物;药物杂质及中间体;标准品;中药对照品;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors |
Mol文件 | 57-37-4.mol |
结构式 |
乙胺痉平 性质
熔点 | 177-179 °C(lit.) |
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储存条件 | Keep in dark place,Sealed in dry,Room Temperature |
溶解度 | DMSO(微溶,加热)、甲醇(微溶) |
形态 | 固体 |
颜色 | 从Me2CO中结晶得到的晶体 |
Merck | 14,1029 |
CAS 数据库 | 57-37-4(CAS DataBase Reference) |
EPA化学物质信息 | Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (57-37-4) |
Target | Value |
Muscarinic receptor
() |
Benactyzine hydrochloride and drofenine are widely used anticholinergic drugs which are also competitive inhibitors of BChE with K i values of 0.010±0.001 and 0.003±0.000 mM, respectively. Results indicate that the inhibition of BChE by Benactyzine hydrochloride is pure or partial competitive. Pure competitive inhibition can be distinguished from partial competitive inhibition by plotting v vs [Benactyzine] at a fixed [BTCh].
Benactyzine hydrochloride (1 mg/kg) does not influence the attention response. Benactyzine hydrochloride increases the duration of the exploratory-motor reaction, but slightly diminishes the salivation elicited by acetylcholine. There is no blocking effect of Benactyzine hydrochloride and promazine on the EEG-seizure activity elicited by acetylcholine, and almost no inhibitory effect on emotional reactions. Emotional reactions are blocked by high doses of imipramine and promazine, but not by Benactyzine hydrochloride. The data indicates that imipramine, promazine and Benactyzine hydrochloride influence the autonomic effects of serotonin in different ways. Promazine, and especially Benactyzine hydrochloride, inhibit and shorten the period of salivation elicited by the intra-amygdaloid injection of serotonin.
安全信息
危险品标志 | T |
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危险类别码 | 23/24/25 |
安全说明 | 36/37/39-45 |
危险品运输编号 | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS号 | DD2800000 |
海关编码 | 2922.50.4000 |
危险等级 | 6.1(b) |
包装类别 | III |
毒性 | LD50 orl-rat: 184 mg/kg TXAPA9 1,42,59 |
提供商 | 语言 |
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英文
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