纳多洛尔
中文名称 | 纳多洛尔 |
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中文同义词 | 苯甲丁氮酮;康格多;纳多洛尔溶液, 100PPM;康加尔多;纳多洛尔;萘丁乐;萘肟洛尔;羟氢萘心安 |
英文名称 | NADOLOL |
英文同义词 | 1-(tert-butylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy);1-(tert-bytylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy)-2;2,3-cis-1,2,3,4-tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naph;2,3-cis-1,2,3,4-Tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol;2,3-cis-1,2,3,4-tetrahydro-5-(2-hydroxy-3-(tert-butylamino)propoxy)-2,3-naphth;2,3-diol;2,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-;2,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-, cis- |
CAS号 | 42200-33-9 |
分子式 | C17H27NO4 |
分子量 | 309.4 |
EINECS号 | 255-706-3 |
相关类别 | 小分子抑制剂;合成;医药原料;RITALIN;Isotopically Labeled Pharmaceutical Reference Standard;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds |
Mol文件 | 42200-33-9.mol |
结构式 |
纳多洛尔 性质
熔点 | 125-130°C |
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沸点 | 449.67°C (rough estimate) |
密度 | 1.0449 (rough estimate) |
折射率 | 1.5420 (estimate) |
储存条件 | Refrigerator |
溶解度 | 微溶于水,易溶于乙醇(96%),几乎不溶于丙酮。 |
形态 | 固体 |
酸度系数(pKa) | 9.67(at 25℃) |
颜色 | 白色至类白色 |
水溶解性 | 8.30g/L(25 ºC) |
BCS Class | 3 |
EPA化学物质信息 | 2,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro- (42200-33-9) |
Target | Value |
β-adrenergic receptor
() |
In human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a K i value of 19.4 μM. With respect to Nadolol, the K m for OATP1A2 is 84 μM.
In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress.
安全信息
WGK Germany | 2 |
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RTECS号 | QJ4870000 |
海关编码 | 2922190900 |
毒害物质数据 | 42200-33-9(Hazardous Substances Data) |
毒性 | LD50 in mice, rats (mg/kg): 4500, 5300 orally (Antonaccio, Evans) |
提供商 | 语言 |
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英文
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