D-谷氨酰胺
中文名称 | D-谷氨酰胺 |
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中文同义词 | D-谷氨酰酸;D-氨羰基丁氨酸;D-麸氨酰胺;D-谷氨酸酰胺;D-谷胺酰胺;谷氨酸盐杂质;D-谷氨酸盐;D-谷氨酸-5-酰胺 |
英文名称 | D-Glutamine |
英文同义词 | D(-)-GLUTAMIC ACID-5-AMIDE;D-GLUTAMIC ACID 5-AMIDE;D-GLUTAMINIC ACID 5-AMIDE;D(-)-GLUTAMINE;D-GLUTAMINE;D-GLUTAMINE extrapure;D-2-Aminoglutaramic acid, D-Glutamic acid 5-amide;Citric Acid, Monohydrate, Crystal, Reagent |
CAS号 | 5959-95-5 |
分子式 | C5H10N2O3 |
分子量 | 146.14 |
EINECS号 | 673-968-0 |
相关类别 | 细胞信号和神经生物学;膦配体;氨基酸类;氨基酸;细胞生物学;氨基酸及其衍生物;生化试剂;其他生化试剂;保护氨基酸;非天然氨基酸;医药中间体、氨基酸衍生物;天然氨基酸极其衍生物;小分子抑制剂,天然产物;化学试剂;中药对照品;对照品;生化试剂-氨基酸类;医用原料;医药原料;D-氨基酸;食品添加剂;Amino ACIDS SERIES;pharmacetical;chiral;Glutamine [Gln, Q];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Amino Acids and Derivatives;amino acid;Inhibitors;杂质对照品;通用生化试剂-氨基酸 |
Mol文件 | 5959-95-5.mol |
结构式 |
D-谷氨酰胺 性质
熔点 | 184-185 °C |
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沸点 | 265.74°C (rough estimate) |
比旋光度 | -32 º (589nm, c=10, N HCl) |
密度 | 1.3394 (rough estimate) |
折射率 | -33 ° (C=5, 5mol/L HCl) |
储存条件 | Keep in dark place,Inert atmosphere,Room temperature |
溶解度 | 水(轻微,超声处理) |
酸度系数(pKa) | 2.27±0.10(Predicted) |
形态 | 粉末 |
颜色 | 白色 |
水溶解性 | 42.53g/L(temperature not stated) |
BRN | 1723796 |
InChIKey | ZDXPYRJPNDTMRX-GSVOUGTGSA-N |
LogP | -1.576 (est) |
CAS 数据库 | 5959-95-5(CAS DataBase Reference) |
Human Endogenous Metabolite
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Glutamine is a key amino acid in the central nervous system (CNS), playing an important role in the glutamate/GABA-Glutamine cycle (GGC). In the GGC,Glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools. D-Glutamine has been used to study its role in conferring protection against acetaldehyde-induced disruption of barrier function in Caco-2 cell monolayer. Role of L-Glutamine in the protection of intestinal epithelium from acetaldehyde-induced disruption of barrier function is evaluated in Caco-2 cell monolayer. L-Glutamine reduced the acetaldehyde-induced decrease in transepithelilal electrical resistance and increase in permeability to inulin and lipopolysaccharide in a time- and dose-dependent manner; D-Glutamine, L-aspargine, L-arginine, L-lysine, or L-alanine produced no significant protection. D-Glutamine also fails to influence the acetaldehyde-induced decrease in TER and increase in inulin flux. D-Glutamine or glutaminase inhibitor by themselves did not influence TER or inulin flux in control or acetaldehyde-treated cell monolayers. Lack of effect of D-Glutamine in protection from acetaldehyde indicates that the L-Glutamine-mediated protection is stereospecific.
安全信息
危险品标志 | Xi |
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危险类别码 | 36/37/38 |
安全说明 | 36/37/39-26-27-24/25 |
WGK Germany | 3 |
海关编码 | 29241900 |
提供商 | 语言 |
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英文
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英文
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