芥子碱
| 中文名称 | 芥子碱 |
|---|---|
| 中文同义词 | 芥子碱(标准品);2-((3-(4-羟基-3,5-二甲氧基苯基)丙烯酰基)氧基)-N,N,N-三甲基乙-1-铵 |
| 英文名称 | Sinapine |
| 英文同义词 | Ethanaminium, 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-;2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl]oxy]-N,N,N-trimethylethanaminium;Sinapic acid choline ester;2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl]oxy]-N,N,N-trimethylethanaminium;2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-N,N,N-trimethylethanaminium;Ethanaminium,2-[[3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-N,N,N-trimethyl-;Sinapin;2-((3-(4-Hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)-N,N,N-trimethylethan-1-aminium |
| CAS号 | 18696-26-9 |
| 分子式 | [C16H24NO5]+. |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | 分析标准品;中药标准品;对照品;对照品;标准品-对照品;标准品，对照品 |
| Mol文件 | 18696-26-9.mol |
| 结构式 |  |
芥子碱 性质
| 熔点 | 178℃ |
|---|---|
| 储存条件 | 4°C, away from moisture and light |
| 溶解度 | DMSO：250 mg/mL（805.52 mM；需要超声波） |
| 形态 | 粉末 |
| LogP | -3.370 (est) |
Sinapine 是一种从十字花科物种的种子中分离出来的生物碱，具有抗氧化、抗肿瘤和放射防护的作用。Sinapine 通过下调 P-glycoprotein 来抑制Caco-2细胞的增殖。
| Target | Value |
|
P-glycoprotein
() |
Sinapine (6 or 60 μM; 1 h) counteracts H
2
O
2
and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes.
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity.
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease.
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.
Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.
用途
用于含量测定/鉴定/药理实验等安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/16 | S3235 | 芥子碱 Sinapine | 18696-26-9 | 1mg | 795.14元 |