芥子酸
| 中文名称 | 芥子酸 |
|---|---|
| 中文同义词 | 咖啡酸反式异构体;芥子酸;3,5-二甲氧基-4-羟基-反式-苯乙烯酸,;3,5-二甲氧基-4-羟基苯丙烯酸;順13-二十二烯酸;順二十二碳-13-烯酸;3,5-二甲氧基-4-羥基桂皮酸;3,5-二甲氧基-4-羟基肉桂酸[ MALDI-TOF/MS基质] |
| 英文名称 | 4-Hydroxy-3,5-dimethoxycinnamic acid |
| 英文同义词 | 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxycinnamic acid, Sinapic acid;3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapic acid, Sinapinic acid;3,5-Dimethoxy-4-hydroxycinnamic acid, 98%, predominantly trans isomer;3-(3,5-Dimethoxy-4-hydroxyphenyl)acrylic acid;3-(4-Hydroxy-3,5-dimethoxyphenyl)propenoic acid;3,5-Dimethoxy-4-hydroxybenzeneacrylic acid;Synapoic acid;3-(4-Hydroxy-3,5-diMethoxyphenyl)-2-propenoic Acid |
| CAS号 | 530-59-6 |
| 分子式 | C11H12O5 |
| 分子量 | 224.21 |
| EINECS号 | 208-487-3 |
| 相关类别 | 营养学研究;羰基化合物;植物提取物;植物生化提取物;医药中间体;生化试剂;对照品;标准品-对照品;Allium cepa (Onion);Allium sativum (Garlic);Armoracia rusticana (Horseradish);Berberis sp.;Building Blocks;C11 to C12;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Cichorium intybus (Chicory);其他生化试剂;生化试剂-其他化学试剂;对照品;苯丙素;标准品，对照品;中药对照品;Aromatic Cinnamic Acids, Esters and Derivatives;Analytical Chemistry;Mass Spectrometry;Matrix Materials (MALDI-TOF-MS);Linum usitatissimum (Flax);Nutrition Research;Organic Building Blocks;Phytochemicals by Plant (Food/Spice/Herb);Vaccinium macrocarpon (Cranberry);UltraPure MALDI Matrices;proteinmod |
| Mol文件 | 530-59-6.mol |
| 结构式 |  |
芥子酸 性质
| 熔点 | ~202 °C |
|---|---|
| 沸点 | 285.61°C (rough estimate) |
| 密度 | 1.1478 (rough estimate) |
| 折射率 | 1.4720 (estimate) |
| 储存条件 | Keep in dark place,Sealed in dry,Room Temperature |
| 溶解度 | H2O：微溶 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 4.53±0.10(Predicted) |
| 颜色 | 白色 |
| 气味 (Odor) | 无味 |
| 水溶解性 | insoluble |
| BRN | 2130006 |
| 稳定性 | 稳定的。与强氧化剂、强碱不相容。易燃。 |
| LogP | 0.997 (est) |
| CAS 数据库 | 530-59-6(CAS DataBase Reference) |
| NIST化学物质信息 | Cinnamic acid, 4-hydroxy-3,5-dimethoxy-(530-59-6) |
Sinapinic acid (Sinapic acid) 是一种天然的小羟基肉桂酸，属于苯基丙烷类，通常在MALDI质谱中用作基质。Sinapinic acid (Sinapic acid) 作为 HDAC 的抑制剂，IC50为2.27 mM，并且还抑制 ACE-1 活性。
| Target | Value |
|
HDAC
() | |
|
ACE1
() |
Sinapinic acid acts as an inhibitor of HDAC, with an IC
50
of 2.27 mM. Sinapinic acid also inhibits ACE-I activity.
Sinapinic acid inhibits HDAC activity in HeLa cells, suppresses the growth of HeLa and HT29 cells with IC
50
s of 0.91 ± 0.02 mM and 1.6 ± 0.02 mM at 72 h, respectively, induces apoptosis of these cancer cells.
Sinapinic acid (5 or 25 mg/kg, p.o. daily for 4 weeks) increases the serum estradiol concentration; decreases insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affects the parameters of antioxidant abilities (reduces glutathione, superoxide dismutase) and oxidative damage in rats.
化学性质
白色粉末，溶于三氯甲烷，乙醚，甲醇，来源于菜粕。用途
用于含量测定/鉴定/药理实验等安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-36-37/39 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| 海关编码 | 29189900 |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-W009732 | Sinapinic acid | 1 g | 300元 | |
| 2024/01/25 | HY-W009732 | 芥子酸 Sinapinic acid | 530-59-6 | 10mM * 1mLin DMSO | 330元 |