水仙环素
中文名称 | 水仙环素 |
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中文同义词 | 水仙环素;水仙环素?, 99.9%;水仙环素对照品;水仙环素标准品;(2S,3R,4S,4AR)-2,3,4,7-四羟基-3,4,4A,5-四氢-[1,3]二氧戊环并[4,5-J]菲啶-6(2H)-酮 |
英文名称 | narciclasine |
英文同义词 | narciclasine;(13β)-1,19-Didehydro-2α,3β,4β,7-tetrahydroxy-11,12-dinor-5,19-secocrinan-6-one;(2S)-3,4,4aβ,5-Tetrahydro-2α,3β,4β,7-tetrahydroxy[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one;Lycorcidinol;(2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one;(2S-(2-alpha,3-beta,4-beta,4a-beta))-3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-(1,3)Dioxolo(4,5-j)phenanthridin-6(2H)-one;3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one;BRN 1087400 |
CAS号 | 29477-83-6 |
分子式 | C14H13NO7 |
分子量 | 307.26 |
EINECS号 | |
相关类别 | 中药对照品;标准品;对照品;植物提取物;细胞周期;标准品-对照品;对照品-中药对照品;标准品 -中药标准品;标准品,对照品 |
Mol文件 | 29477-83-6.mol |
结构式 |
水仙环素 性质
熔点 | 250-252℃ |
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沸点 | 447.77°C (rough estimate) |
密度 | 1.85±0.1 g/cm3 (20 ºC 760 Torr) |
折射率 | 1.5300 (estimate) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:≥10mg/mL |
酸度系数(pKa) | 7.72±0.70(Predicted) |
形态 | 固体 |
颜色 | 白色至类白色 |
ROCK
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Narciclasine activates Rho and stress fibers in glioblastoma multiforme cells. The mean IC 50 of ~50 nM calculated on the 6 human glioblastoma multiforme (U373, Hs683, GL19, GL5, GL16, GL17), The mean IC 50 value of 47 nM for Narciclasine across a panel of 60 cancer cell lines. Bioassay-guided fractionation of the A. belladonna extract resulted in the identification of lycorine as the bio-active compound. The IC 50 measured for radicle growth inhibition is 0.1 µM for Narciclasine.
The i.v. regimen of Narciclasine at 1 mg/kg significantly (P=0.02) increases the survival of GL19 glioblastoma multiforme-bearing mice. Narciclasine when given orally at the same dose five times a week for 5 consecutive weeks also significantly increases animal survival in this model (P=0.008). Oral treatment with Narciclasine at 1 mg/kg significantly increases the survival (P=0.004) of Hs683 glioblastoma multiforme-bearing mice. Increasing the number of doses administered per week does not increase the survival of these Hs683 glioblastoma multiforme-bearing mice. Narciclasine appears to show similar increased survival in these models to temozolomide but at appreciable lower doses and following both oral and i.v. administration.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-16563 | 水仙环素 Narciclasine | 29477-83-6 | 1mg | 1180元 |
2024/08/19 | HY-16563 | 水仙环素 Narciclasine | 29477-83-6 | 5mg | 4750元 |