奈斯布维
中文名称 | 奈斯布维 |
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中文同义词 | 5-环丙基-2-(4-氟苯基)-6-[(2-羟基乙基)(甲基磺酰基)氨基]-N-甲基-3-苯并呋喃甲酰胺;奈斯布维;化合物NESBUVIR |
英文名称 | Nesbuvir |
英文同义词 | 5-Cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-3-benzofurancarboxamide;nesbuvir = HCV-796;HCV-796 (Nesbuvir);5-Cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-3-benzofurancarboxamide Nesbuvir HCV 796;HCV 796;Nesbuvir;VB-19796);CS-1844 |
CAS号 | 691852-58-1 |
分子式 | C22H23FN2O5S |
分子量 | 446.49 |
EINECS号 | |
相关类别 | |
Mol文件 | 691852-58-1.mol |
结构式 |
奈斯布维 性质
密度 | 1.407 |
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储存条件 | Store at -20°C |
溶解度 | DMSO 中≥22.3 mg/mL;不溶于水;温和加热时,EtOH 中≥97.8 mg/mL |
形态 | 固体 |
酸度系数(pKa) | 13.88±0.46(Predicted) |
颜色 | 白色至米白色 |
EC50: 9 nM (NS3 V170A ), 13 nM (NS3 V170A ), 15 nM (NS3 K583T ), 13 nM (NS5B I424V )
Replicon cells are treated with 1 mg/mL G418 and combinations of the two compounds. Nesbuvir (HCV-796) is added to 40 or 80 nM (approximately 10 and 20 times the EC 50 in a 3-day replicon inhibition assay, respectively) and Boceprevir is added to 400 or 800 nM (approximately 2 and 4 times the EC 50 , respectively). The EC 50 s for Nesbuvir and Boceprevir for the parental replicon in the transient expression assay are comparable to those obtained in the 3-day inhibition assay with the stable replicon cells; the EC 50 for Nesbuvir in the transient expression assay is 14 nM, whereas it is 5 nM for the stable replicon; and the EC 50 for Boceprevir in the transient expression assay is 608 nM, whereas it is 201 nM for the stable replicon.
Among a huge variety of yet characterized nucleoside and non-nucleoside inhibitors (NNI), the benzofurane derivative NNI Nesbuvir (HCV-796) is demonstrated to yield significant antiviral effects in mice with chimeric human livers and in patients infected with HCV. HCV-796 binds to a hydrophobic binding pocket at the “palm” domain of NS5B; however, its mode of inhibition remains to be defined.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-14775 | 5-环丙基-2-(4-氟苯基)-6-[(2-羟基乙基)(甲基磺酰基)氨基]-N-甲基-3-苯并呋喃甲酰胺 Nesbuvir | 691852-58-1 | 5mg | 2200元 |
2024/08/19 | HY-14775 | 5-环丙基-2-(4-氟苯基)-6-[(2-羟基乙基)(甲基磺酰基)氨基]-N-甲基-3-苯并呋喃甲酰胺 Nesbuvir | 691852-58-1 | 10mM * 1mLin DMSO | 2420元 |