二氯尼特
中文名称 | 二氯尼特 |
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中文同义词 | 二氯尼特 |
英文名称 | diloxanide |
英文同义词 | diloxanide;α,α-Dichloro-4'-hydroxy-N-methylacetanilide;2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide;2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-acetamide;2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-ethanamide;Acetamide, 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-;diloxanide USP/EP/BP;Diloxanid |
CAS号 | 579-38-4 |
分子式 | C9H9Cl2NO2 |
分子量 | 234.08 |
EINECS号 | 2094394 |
相关类别 | 原料 |
Mol文件 | 579-38-4.mol |
结构式 |
二氯尼特 性质
熔点 | 175° |
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沸点 | 356.2±42.0 °C(Predicted) |
密度 | 1.439±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:33.33(最大浓度 mg/mL);142.39(最大浓度 mM) |
形态 | 固体 |
酸度系数(pKa) | 9.95±0.15(Predicted) |
颜色 | 浅棕色至棕色 |
Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate.Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats.