4-(甲氨基)安替比林
中文名称 | 4-(甲氨基)安替比林 |
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中文同义词 | 4-(甲基氨基)安替比林;咪达唑仑杂质C;2,3-二甲基-4-甲基-1-苯基-3-吡唑啉-5-酮;1,2-二氢-1,5-二甲基-4-(甲基氨基)-2-苯基-3H-吡唑-3-酮;4-(甲氨基)安替比林;安替比林,4-(甲基氨基)-;乙二醇甲酸乙醚1,5-二甲基-4-(甲基氨基)-2-苯基-;4-单甲基氨基安替比林 |
英文名称 | 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one |
英文同义词 | noramidopyrine;4-(Methylamino)-antipyrine;2,3-Dimethyl-4-methylamino-1-phenyl-3-pyrazolin-5-one;Methylaminoantipyrine;Monomethylaminoantipyrine;Noraminopyrine;1,5-Dimethyl-4-(methylamino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride;N-Methylaminophenazone |
CAS号 | 519-98-2 |
分子式 | C12H15N3O |
分子量 | 217.27 |
EINECS号 | 208-281-3 |
相关类别 | 其他兽药标准品;对照品-杂质对照品;中药对照品;标准品;药物杂质及中间体;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals |
Mol文件 | 519-98-2.mol |
结构式 |
4-(甲氨基)安替比林 性质
熔点 | 50-53°C |
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沸点 | 324.5±45.0 °C(Predicted) |
密度 | 1.20±0.1 g/cm3 (20 ºC 760 Torr) |
储存条件 | -20°C Freezer |
溶解度 | 可溶于氯仿(少许)、乙酸乙酯(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 4.76±0.20(Predicted) |
颜色 | 淡黄色至棕色油状 |
COX
Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.
The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentrations of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.
安全信息
危险等级 | IRRITANT |
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毒性 | LD50 oral in mouse: 7gm/kg |