石蒜碱盐酸盐
中文名称 | 石蒜碱盐酸盐 |
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中文同义词 | 石蒜碱盐酸盐;石蒜碱 HPL;石蒜鹼;水仙鹼;石蒜提取物.石蒜碱;LYCORINE 石蒜碱;石蒜碱(水仙碱);石蒜碱 |
英文名称 | LYCORINE |
英文同义词 | 2-beta-diol,3,3-alpha-didehydro-lycoran-1-alph;Amaryline;amarylline;Belamarine;galanthan-1,2-diol,3,12-didehydro-9,10-(methylenebis(oxy))-,(1-alpha,2-beta;galanthidine;narcissine;LYCORINE HPLC 98+% |
CAS号 | 476-28-8 |
分子式 | C16H17NO4 |
分子量 | 287.31 |
EINECS号 | 207-503-6 |
相关类别 | 中草药成分;中药对照品;植物提取物;对照品;标准品;分析试剂标准品;对照品-中药对照品;Alkaloids;生物碱;标准品 -中药标准品;标准品,对照品;通用生化试剂-天然产物 |
Mol文件 | 476-28-8.mol |
结构式 |
石蒜碱盐酸盐 性质
熔点 | 253-255℃ (dec.) |
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比旋光度 | D16 -129° (c = 0.16 in 98% alc) |
沸点 | 429.61°C (rough estimate) |
密度 | 1.53 |
折射率 | 1.5500 (estimate) |
储存条件 | 2-8°C |
溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
酸度系数(pKa) | 13.55±0.40(Predicted) |
形态 | 粉末 |
颜色 | 白色至米白色 |
旋光性 (optical activity) | -12916 (c 0.16, 98% ethanol) |
Kd: 15.24 nM (SCAP)
Lycorine inhibits cell proliferation in a dose-dependent manner in the abovementioned 4 PCa cell lines, and the IC 50 ranged from 5 μM to 10 μM., it also shows Lycorine has little effects on PNT1A cell's proliferation.SCAP (SREBF chaperone) is an ER-toGolgi transport protein, undergoes a conformational change, and regulates/preserves SREBFs in the ER by forming a complex with INSIG1 (insulin induced gene 1).Lycorine (5-40 μM; 16 hours) significantly suppresses SREBFs activity (up to -70%) in a dosedependent manner and does not cause obvious cytotoxicity in cells.Lycorine (10-20 μM; 2-16 hours) dose- and time-dependently decreases the mature SREBF1 and SREBF2 proteins in HL-7702 cells.Lycorine (20 μM; 16 hours) neither activates NR1H3 transcription nor affect NR1H3 target genes, including ABCG5 and ABCG8, but Sterols activates NR1H3 transcription activity.Lycorine hydrochloride (0-25 μM; 48 hours) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.Lycorine hydrochloride (0-25 μM; 48 hours) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
Cell Viability Assay
Cell Line: | HL-7702/SRE-Luc cells |
Concentration: | 16 hours |
Incubation Time: | 5 μM; 10 μM; 20 μM; 40 μM |
Result: | Had no cytotoxicity on HL-7702 cells. |
Western Blot Analysis
Cell Line: | HL-7702/SRE-Luc cells |
Concentration: | 2 hours, 4 hours, 8 hours, 12 hours, 16 hours |
Incubation Time: | 10 μM; 20 μM |
Result: | Decreased p-SREBF1, m-SREBF1, p-SREBF2 and p-SREBF1 protein expression. |
RT-PCR
Cell Line: | C8161 cells |
Concentration: | 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM |
Incubation Time: | 48 hours |
Result: | Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells. |
Lycorine (oral chow; 15 mg/kg, 30 mg/kg; once daily) alleviates fat accumulation and metabolic syndrome, increases lipolysis and betaoxidation of fatty acid along with precursor and mature SREBFs in mice .
Animal Model: | High-fat diet (HFD)-fed C57BL/6J mice |
Dosage: | 15 mg/kg, 30 mg/kg |
Administration: | Oral chow; once daily |
Result: | Ameliorated high-fat diet-induced hyperlipidemia, hepatic steatosis, and insulin resistance in mice. |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N0288 | 石蒜碱盐酸盐 Lycorine | 476-28-8 | 50mg | 800元 |
2024/08/19 | HY-N0288 | Lycorine | 10 mM * 1 mLin DMSO | 880元 |