N-去甲基三苯氧胺 盐酸盐
中文名称 | N-去甲基三苯氧胺 盐酸盐 |
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中文同义词 | 2-[4-[(1Z)-1,2-二苯基-1-丁烯基]苯氧基]-N-甲基乙胺盐酸盐;N-去甲基三苯氧胺 盐酸盐/N-去甲基他莫昔芬盐酸盐;N-去甲基三苯氧胺 盐酸盐;N-去甲基他莫昔芬盐酸;N-去甲他莫昔芬盐酸盐;他莫昔芬杂质F (EP);枸橼酸他莫昔芬杂质F(EP) 标准品;枸橼酸他莫昔芬杂质6 |
英文名称 | N-Desmethyl Tamoxifen Hydrochloride |
英文同义词 | N-Demethyltamoxifen Hydrochlorid;(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N-methylethanamine Hydrochloride;Nsc372964;2-[4-[(1Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N-methylethanamine hydrochloride;(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine;Tamoxifen Citrate EP Impurity F HCl;2-[4-[(Z)-1,2-Diphenylbut-1-enyl]ph;Tamoxifen EP Impurity F HCl |
CAS号 | 15917-65-4 |
分子式 | C25H27NO.ClH |
分子量 | 393.955 |
EINECS号 | |
相关类别 | 杂质对照品;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Various Metabolites and Impurities |
Mol文件 | 15917-65-4.mol |
结构式 |
N-去甲基三苯氧胺 盐酸盐 性质
熔点 | 225-227°C |
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储存条件 | room temp |
溶解度 | 二甲基亚砜:≥20mg/mL |
形态 | 固体 |
颜色 | 白色至米白色 |
稳定性 | 感光 |
N-desmethyltamoxifen hydrochloride (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
N-desmethyltamoxifen hydrochloride (1.5-10 μM; 114 hours) inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen hydrochloride, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.
Cell Viability Assay
Cell Line: | MCF 7 human mammary carcinoma cells |
Concentration: | 1.5, 2.5, 5, 7.5, 10 μM |
Incubation Time: | 114 hours |
Result: | Inhibits growth of MCF 7 human mammary carcinoma cells |
安全信息
危险品标志 | T,N |
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危险类别码 | 45-46-60-50/53 |
安全说明 | 53-45-60-61 |
危险品运输编号 | UN 3077 9 / PGIII |
WGK Germany | 3 |