人内皮素3
中文名称 | 人内皮素3 |
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中文同义词 | 小鼠内皮素-3;人内皮素3;人内皮素3, ≥97% (HPLC), POWDER;内皮素-3;内皮素 3 人,大鼠,三氟乙酸盐 |
英文名称 | H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH |
英文同义词 | ENDOTHELIN-III, HUMAN, RAT;ENDOTHELIN-3;ENDOTHELIN-3, HUMAN;ENDOTHELIN 3, HUMAN AND RAT;ENDOTHELIN-3 (HUMAN, MOUSE, RABBIT, RAT);ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT);ENDOTHELIN 3 HUMAN, RAT;ENDOTHELIN-3 (HUMAN, RAT, PIG) |
CAS号 | 117399-93-6 |
分子式 | C121H168N26O33S4 |
分子量 | 2643.04 |
EINECS号 | |
相关类别 | 细胞生物学;细胞信号和神经生物学;Peptide;Endothelin receptor |
Mol文件 | 117399-93-6.mol |
结构式 |
人内皮素3 性质
密度 | 1.285±0.06 g/cm3(Predicted) |
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储存条件 | −20°C |
形态 | 粉末 |
颜色 | 白色 |
水溶解性 | Soluble to 1 mg/ml in water |
ET-RA, ET-RB
The endothelins (ETs) are a family of 21-amino-acid vasoconstrictor peptides comprising three distinct isoforms: ET-1, ET2 and Endothelin-3. Endothelin-3 is detected in plasma, heart, brain and vascular smooth muscle cells (VSMCs). The surface enzymes of VSMCs break down big Endothelin-3 to the corresponding mature peptide, Endothelin-3. Endothelin-3 down-regulate endothelin ETA receptor expression in coronary artery VSMCs without affecting receptor density or functional ETA receptor responses. By contrast, high concentrations of Endothelin-3 (100 nM) increase the expression of ETB receptors but abolish the vasoconstrictor response of the receptors, possibly due to the desensitizing effect of Endothelin-3. Endothelin-3 stimulates ENCC adhesion to various ECM components. Endothelin-3 induces rapid changes in ENCC shape and protrusion dynamics favouring sustained growth and stabilization of lamellipodia, a process coincident with the increase in the number of focal adhesions and activated β1-integrins.
Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity.
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英文
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