知母皂苷BII
| 中文名称 | 知母皂苷BII |
|---|---|
| 中文同义词 | 知母皂苷B2;知母皂苷BII(标准品);知母皂苷BII;TIMOSAPONIN BII 知母皂苷BII;知母皂苷 BII, 来源于知母;TIMOSAPONIN BII 知母皂苷BII 标准品;知母皂苷BⅡ(分析标准品);知母皂苷BII、原知母皂苷A3 |
| 英文名称 | Timosaponin BII |
| 英文同义词 | Timosaponin B2;Timsaponin B-Ⅱ;Timosaponin BII;(25S)-26-(β-D-Glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-5β-furostan-22-ol;(25S)-3β-[(2-O-β-D-Glucopyranosyl-β-D-galactopyranosyl)oxy]-26-(β-D-glucopyranosyloxy)-5β-furostane-22-ol;Anemarsaponin BII, 98%, from Anemarrhena asphodeloides Bunge;Prototimosaponin A III;β-D-Galactopyranoside, (3β,5β,22α,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl- |
| CAS号 | 136656-07-0 |
| 分子式 | C45H76O19 |
| 分子量 | 921.08 |
| EINECS号 | |
| 相关类别 | 中药对照品;标准品;对照品;植提标准品;对照品,标准品;植物提取物;分析试剂标准品;标准品-对照品;Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;对照品-中药对照品;标准品 -中药标准品;其它萜类;标准品，对照品 |
| Mol文件 | 136656-07-0.mol |
| 结构式 |  |
知母皂苷BII 性质
| 沸点 | 1033.6±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.43 |
| 闪点 | 573℃ |
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL；乙醇：微溶； PBS（pH 7.2）：5 mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 12.85±0.70(Predicted) |
Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC 50 value of 15.5 μg/mL in the HL-60 cells.
Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time.
安全信息
| 海关编码 | 29389090 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N0812 | Timosaponin BII | 1 mg | 304元 | |
| 2024/01/25 | HY-N0812 | 知母皂苷BII Timosaponin BII | 136656-07-0 | 5mg | 880元 |