苯噻啶苹果酸盐
| 中文名称 | 苯噻啶苹果酸盐 |
|---|---|
| 中文同义词 | 9,10-二氢-4-(1-甲基哌啶-4-亚基)-4H-苯并[4,5]环庚烷并[1,2-b]噻吩苹果酸盐 (1:1);苯噻啶苹果酸酯;苯噻啶苹果酸盐;苯噻啶苹果酸盐(偏头痛);双氯芬酸苹果酸盐;苹果酸苯噻;PIZOTIFEN苹果酸;4-(9,10-二氢-4H-苯并[4,5]环庚[1,2-B]噻吩-4-亚基)-1-甲基哌啶 2-羟基琥珀酸盐 |
| 英文名称 | Pizotifen Malate |
| 英文同义词 | sandomygranmalate;sanomtgran;4-(9,10-DIHYDRO-1-THIA-BENZO[F]AZULEN-4-YLIDENE)-1-METHYL-PIPERIDINE, COMPOUND WITH 2-HYDROXY-SUCCINIC ACID;PIZOTYLINE MALATE;PIZOTIFEN MALATE;9,10-Dihydro-4-(1-methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophene malate (1:1);malic acid, compound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine (1:1);Einecs 225-970-4 |
| CAS号 | 5189-11-7 |
| 分子式 | C23H27NO5S |
| 分子量 | 429.53 |
| EINECS号 | 225-970-4 |
| 相关类别 | 其他科研原料药;小分子抑制剂;医药原料;化合物：原料药;医药化工类;原料中间体-原料药;Active Pharmaceutical Ingredients;Sandomigran, pizotyline;医用原料;原料药;医药原料药;医药、农药及染料中间体;日用化学品;化工原料;生物试剂;科研原料 |
| Mol文件 | 5189-11-7.mol |
| 结构式 |  |
苯噻啶苹果酸盐 性质
| 熔点 | 185-186° (dec) |
|---|---|
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 溶解度 | 酸水溶液（微溶，加热）、DMSO（微溶）、甲醇（微溶） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
|
5-HT 2A Receptor
|
5-HT 1C Receptor
|
Pizotifen malate (BC-105 malate) is a potent 5-HT 2 receptor antagonist, with a high affinity for 5-HT 1C binding site. Pizotifen is an antidepresent 5-HT 2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation.
The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate) ; the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-B0115A | Pizotifen malate | 100 mg | 200元 | |
| 2024/04/30 | S1394 | 苯噻啶苹果酸盐 Pizotifen Malate | 5189-11-7 | 50mg | 804.86元 |