串珠镰刀菌素
中文名称 | 串珠镰刀菌素 |
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中文同义词 | 3-羟基-3-环丁烯二酮钠盐;串珠镰刀菌素;串珠镰刀菌素钾盐;化合物 T13777;MONILIFORMIN SODIUM SALT BIOCHEMICA;串珠镰刀菌素钾盐, 来源于镰刀菌;串珠镰刀菌素钠盐;MONILIFORMIN (NATRIUM SALT) |
英文名称 | 1-HYDROXYCLOBUT-1-ENE-3,4-DIONE SODIUM SALT |
英文同义词 | moniliformin sodium salt from fusarium proliferatum;Moniliformin sodium salt from Fusarium moniliforme;monobutyryl cyclic 3',5'-adenosine monophosphate, sodium;3-Cyclobutene-1,2-dione, 3-hydroxy-, sodium salt;3-Hydroxy-3-cyclobutenedione sodium salt;Ccris 7906;Moniliformin sodium salt from Fusarium proliferatum,1-Hydroxycyclobut-1-ene-3,4-dione;Sodium 3,4-dioxocyclobut-1-en-1-olate |
CAS号 | 71376-34-6 |
分子式 | C4H3NaO3 |
分子量 | 122.05 |
EINECS号 | |
相关类别 | 微生物代谢物;抗生素;医药原料;antibiotic |
Mol文件 | 71376-34-6.mol |
结构式 |
串珠镰刀菌素 性质
闪点 | 2℃ |
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储存条件 | 2-8°C |
溶解度 | 水中≤10mg/ml |
形态 | 淡黄色粉末。 |
颜色 | 浅黄至黄色 |
Fusarium moniliforme NRRL 6322 produces about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. Several strains of Fusarium moniliforme produce in laboratory culture more than 800 mg of moniliformin per kg of growth substrate. Monocytes-derived macrophages exposed to moniliformin during the differentiation process present a decrease of endocytosis ability, and a decrease of CD71 and HLA-DR expression.
Moniliformin is less toxic to mice, with an LD 50 of 20.9 mg per kg for the females and 29.1 mg per kg of body weight for the males. As in the case of the chicks, mice surviving the toxin demonstrated no ill effects; the mice or chicks that died became recumbent in 4 to 6 h after treatment and died within 24 h. In 4-day-old chicken embryos, a sharp LD 50 of 2.8 μg per embryo is obtained with no overt gross teratogenic effects in the survivors. Rats treated with the highest dose of moniliformin show decreased activity followed by acute heart failure and death. The rats of the lower doses (<9mg/kg b.w.) show no signs of toxicity. The daily intake of moniliformin strongly reduces the phagocytic activity of neutrophils in all dose groups. The decrease continued in the satellite group during the follow-up period, indicating a severe impact on the immune system and a LOAEL value of 3mg/kg b.w. for moniliformin. Moniliformin is rapidly excreted into urine, ranging between 20.2 and 31.5% daily and shows no signs of accumulation. The concentration of moniliformin in faeces is less than 2%, which suggests efficient absorption from the gastrointestinal tract.
安全信息
危险品标志 | T,Xn,F |
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危险类别码 | 25-36-20/21/22-11 |
安全说明 | 45-36/37-16 |
危险品运输编号 | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS号 | GU1815000 |
海关编码 | 29144000 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101905 | 串珠镰刀菌素 Moniliformin sodium salt | 71376-34-6 | 1mg | 1700元 |
2024/08/19 | HY-101905 | 串珠镰刀菌素 Moniliformin sodium salt | 71376-34-6 | 10mM * 1mLin DMSO | 2245元 |