1,1-diMethyl-2,3-dihydro-1H-inden-5-aMine synthesis
- Product Name:1,1-diMethyl-2,3-dihydro-1H-inden-5-aMine
- CAS Number:64278-19-9
- Molecular formula:C11H15N
- Molecular Weight:161.24
67159-79-9
7 suppliers
inquiry
64278-19-9
9 suppliers
inquiry
Yield:64278-19-9 44%
Reaction Conditions:
with methanesulfonic acid;10 wt% Pd(OH)2 on carbon;hydrogen in methanol; under 2585.81 Torr; for 1.5 h;
Steps:
14.b
In a Parr shaker flask containing 3,3-dimethyl-6-nitro-1-indanone (1.0 g, 4.8 mmol) and palladium hydroxide on carbon (Pd(OH)2, 20% by weight, 0.52 g) in methanol (2 mL) and methane sulfonic acid (MeSO3H, 0.4 mL, 6.2 mmol) was hydrogenated at 50 psi for 1.5 h. The reaction mixture was diluted with methanol and filtered through a pad of Celite. The filtrate was concentrated in vacuo and the resulting crude residue was purified by flash chromatography (SiO2, 100% ethyl acetate) to give the desired product (0.34 g, 2.1 mmol, 44%).
References:
US2013/225580,2013,A1 Location in patent:Paragraph 0160; 0162
64278-18-8
1 suppliers
inquiry
64278-19-9
9 suppliers
inquiry
26465-81-6
111 suppliers
$12.00/1g
64278-19-9
9 suppliers
inquiry