1-(1-METHYL-1H-IMIDAZOL-2-YLMETHYL)-PIPERAZINE synthesis

Yield:880361-71-7 67%

Reaction Conditions:

with hydrogenchloride in ethanol at 20; for 8 h;

Steps:

24.b b) 1 -[(1 -Methyl-1H-imidazol-2-yl)methyl]piperazine

A mixture of ie tert-butyl 4-[(1 -methyl-1H-imidazol-2-yl)methyl]piperazine-1 -carboxylate (Preparation 24a, 0.59 g, 2.10 mmol) and 1 .25 M hydrogen chloride solution in ethanol (30 mL) was stirred at ambient temperature for 8h. The solvent was evaporated and the residue was treated with diethyl ether, filtered, washed with acetonitrile and dried to yield the hydrochloride salt of the title compound (0.46 g, 67%) as a white solid. LRMS (m/z): 181 (M+1 )⁺

References:

WO2015/91531,2015,A1 Location in patent:Page/Page column 47