1,2,3,4-tetrahydro-1- methyl-7-fluoroisoquinoline synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride;sodium borohydrid in methanol;

Steps:

2.3 Step 3

Step 3 1-methyl-7-fluoro-1,2,3,4-tetrahydroisoquinoline To the solution of 1-methyl-7-fluoro-3,4-dihydroisoquinoline (2.4 g, 14.7 mmol) prepared in Step 2in methanol (10 ml), sodium borohydride (0.28 g, 1 eq.) was portionwise added. The reaction mixture was stirred for 3 hours and 1N hydrochloric acid solution (20 ml) was added thereto. The reaction mixture was washed with dichloromethane. The water layer was adjusted to pH 12 with potassium hydroxide solution and extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to give 2.0 g of the titled compound.

References:

US6545008,2003,B1