1-(2,4,6-TRIMETHOXY-PHENYL)-PROP-2-YN-1-OL synthesis
2synthesis methods
- Product Name:1-(2,4,6-TRIMETHOXY-PHENYL)-PROP-2-YN-1-OL
- CAS Number:61040-72-0
- Molecular formula:C12H14O4
- Molecular Weight:222.24
Yield:61040-72-0 65%
Reaction Conditions:
Stage #1: 2,4,6-trimethoxybenzaldehyde;acetylenemagnesium bromide in tetrahydrofuran at 0 - 20;
Stage #2: with water;ammonium chloride in tetrahydrofuran;
References:
Reddy, M. V. Ramana;Akula, Balaiah;Cosenza, Stephen C.;Lee, Clement M.;Mallireddigari, Muralidhar R.;Pallela, Venkat R.;Subbaiah, D. R. C. Venkata;Udofa, Andrew;Reddy, E. Premkumar [Journal of Medicinal Chemistry,2012,vol. 55,# 11,p. 5174 - 5187] Location in patent:experimental part
