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1-(2,6-Difluorophenyl)ethan-1-amine synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; Trametes versicolor laccase / tert-butyl methyl ether / 16 h / 30 °C / pH 5 / Enzymatic reaction
2: sodium cyanoborohydride; ammonium acetate / methanol / 24 h / 20 °C

References:

Martínez-Montero, Lía;Gotor, Vicente;Gotor-Fernández, Vicente;Lavandera, Iván [Green Chemistry,2017,vol. 19,# 2,p. 474 - 480]