1,2-Benzenediol, 4-bromo-5-fluoro- (9CI) synthesis
- Product Name:1,2-Benzenediol, 4-bromo-5-fluoro- (9CI)
- CAS Number:656804-73-8
- Molecular formula:C6H4BrFO2
- Molecular Weight:207
398-62-9
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656804-73-8
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$220.00/50mg
Yield:656804-73-8 98%
Reaction Conditions:
Stage #1: 4-fluoroveratrolewith boron tribromide in dichloromethane at -78 - 20;
Stage #2: with bromine in tetrachloromethane;dichloromethane;chloroform; for 3 h;
Steps:
108.a a) Preparation [OF 4-BROMO-5-FLUORO-BENZENE-1,] 2-diol
To a cooled [(-78°C)] solution [OF 4-FLUOROVERATROLE] (5.0 g, 32 mmol) in dichloromethane (106 mL) was slowly added a solution of tribromoborane in dichloromethane (1M, 96 mL, 96 mmol, 3.0 eq. ). The reaction mixture was warmed to [20°C] and stirred overnight. The reaction mixture was poured into ice water, extracted with ethyl acetate (3 times). The combined organic layer was washed with an aqueous solution of sodium bicarbonate, dried over sodium sulfate and filtered. The volatiles were removed in vacuo. The brown solid was diluted with chloroform (50 mL) and dichloromethane (10 mL). A solution of bromine in carbon tetrachloride (5 ml) was slowly added. After 3 hours, the volatiles were removed in vacuo. Purification by flash chromatography afforded the title compound (6.51 g, 98%) as a brown solid
References:
WO2004/13120,2004,A1 Location in patent:Page 111-112
886510-25-4
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656804-73-8
43 suppliers
$220.00/50mg
367-32-8
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$28.00/1g
656804-73-8
43 suppliers
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1095544-81-2
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$39.00/1g
656804-73-8
43 suppliers
$220.00/50mg