1-(2-Chloropyridin-3-yl)-3-phenylthiourea synthesis

Yield:69437-72-5 71.8%

Reaction Conditions:

in dichloromethane at 0; for 0.75 h;

Steps:

36 4.2 General procedure for the synthesis of compounds 1-38

General procedure: 3-Chlorophenyl isothiocyanate and phenyl isothiocyanate (1.9 mmol and 3.7 mmol) was dissolved in 10 mL dichloromethane at 0 °C. Then aniline (2.7 mmol and 5.5 mmol), was added dropwise with constant stirring, and completion of reaction is checked by TLC analysis. After 45 min a white solid appeared, the resultant solid product was filtered, washed with hexane, triturated with 10 mL of dichloromethane and excess of hexane and dried under vacuum. Recrystallization with methanol afforded the desired solid thiourea 1-38.

References:

Khan, Khalid Mohammed;Naz, Farzana;Taha, Muhammad;Khan, Ajmal;Perveen, Shahnaz;Choudhary;Voelter, Wolfgang [European Journal of Medicinal Chemistry,2014,vol. 74,p. 314 - 323]